Can Smallpox Be Genetic?

Can Smallpox Be Genetic? Can smallpox be genetic? Resistance To HIV Does smallpox have DNA as genetic material? Smallpox is caused by the Variola virus, a member of the genus Orthopoxvirus. It’s genome consists of a single, linear double-stranded DNA molecule made up of 186,102 base pairs. There are 10 enzymes that regulate gene expression,