Aztreonam is a monobactam antibiotic that was approved in 1986 for the treatment of Gram-negative bacterial infections via intravenous or intramuscular injection (Azactam®) [20]. This drug was marketed to treat bacterial infections and is safe for patients with penicillin allergies [21].
Is aztreonam a broad spectrum antibiotic?
Aztreonam exhibits potent and specific activity in vitro against a wide spectrum of gram-negative aerobic pathogens including Pseudomonas aeruginosa. It has no useful activity against gram-positive bacteria or anaerobes, but has very broad spectrum against gram-negative aerobes, including Pseudomonas aeruginosa.
What type of antibiotic is aztreonam?
Aztreonam (azthreonam; SQ 26,776) is the first member of a new class of beta-lactam antibiotics , the monobactams. Aztreonam is selectively active against Gram-negative aerobic bacteria and inactive against Gram-positive bacteria.
What drug class does aztreonam belong to?
Aztreonam is in a class of medications called monobactam antibiotics . It works by killing bacteria. Antibiotics such as aztreonam injection will not work for colds, flu, or other viral infections.
Is aztreonam a cephalosporin?
Aztreonam is bactericidal , but less so than some of the cephalosporins.
Is azactam good for UTI?
AZACTAM is indicated for the treatment of the following infections caused by susceptible Gram-negative microorganisms: Reference ID: 3326494 Page 10 10 Urinary Tract Infections (complicated and uncomplicated), including pyelonephritis and cystitis (initial and recurrent) caused by Escherichia coli, Klebsiella ...
Is Monobactam broad spectrum?
Monobactams are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity , and have a structure which renders them highly resistant to beta-lactamases.
Is aztreonam cross allergenic with penicillin?
Aztreonam may be safely administered to patients with a history of penicillin allergy . Caution is warranted, however, in patients who are allergic to ceftazidime and are subsequently placed on aztreonam therapy.
How effective is aztreonam?
Therapeutic trials have shown aztreonam to be effective in Gram-negative infections including complicated infections of the urinary tract, in lower respiratory tract infections and in gynaecological and obstetric, intra-abdominal, joint and bone, skin and soft tissue infections, uncomplicated gonorrhoea and septicaemia ...
What are the contraindications of aztreonam?
- diarrhea from an infection with Clostridium difficile bacteria.
- liver problems.
- decreased kidney function.
How long should you use aztreonam?
The duration of therapy depends on the severity of infection. Generally, AZACTAM should be continued for at least 48 hours after the patient becomes asymptomatic or evidence of bacterial eradication has been obtained. Persistent infections may require treatment for several weeks.
When should I take aztreonam?
Aztreonam is usually given as long as needed until your infection has cleared , or until you have been symptom-free for at least 48 hours. Use this medicine for the full prescribed length of time, even if your symptoms quickly improve.
Does aztreonam cover MRSA?
MRSA infections are staphylococcal infections that are resistant to beta-lactam antibiotics including: penicillin, ampicillin, amoxicillin, amoxicillin/clavulanate, methicillin, oxacillin, dicloxacillin, nafcillin, cephalosporins, carbapenems (e.g., imipenem), and the monobactams (e.g., aztreonam).
What type of antibiotic is ceftriaxone?
Ceftriaxone is a cephalosporin (SEF a low spor in) antibiotic. Ceftriaxone is used to treat many kinds of bacterial infections, including severe or life-threatening forms such as E. coli, pneumonia, or meningitis.
Does tetracycline have penicillin in it?
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Tetracyclines are unrelated to penicillins and therefore are safe to take in hypersensitive patients. Other unrelated antibiotics include quinolones (e.g. ciprofloxacin), macrolides (e.g. clarithromycin), aminoglycosides (e.g. gentamicin) and glycopeptides (e.g. vancomycin).
What class of antibiotic is imipenem?
Imipenem, the first of a new class of carbapenem antibiotics , has potent activity against most clinically important species of bacteria, including isolates resistant to other antibiotics.
