Contraindications to raloxifene include past medical history of deep venous thrombosis, renal vein thrombosis, pulmonary embolism, malignancy, active smoking , or any thrombophilia (factor V Leiden deficiency, prothrombin gene mutation G20210A, antiphospholipid syndrome, deficiency of antithrombin, protein c and s ...
Is raloxifene safe to take?
Raloxifene is associated with an increased risk of deep vein thrombosis , pulmonary embolism, and retinal vein thrombosis. An increased risk of death due to stroke was observed in a trial in postmenopausal women with documented coronary heart disease or at increased risk for major coronary events.
Who should not take raloxifene?
Raloxifene is associated with an increased risk of deep vein thrombosis , pulmonary embolism, and retinal vein thrombosis. An increased risk of death due to stroke was observed in a trial in postmenopausal women with documented coronary heart disease or at increased risk for major coronary events.
Does raloxifene cause high blood pressure?
In all the groups, blood pressure remained unchanged. Conclusion: Raloxifene may have no significant effect on the RAAS or blood pressure in hypertensive and normotensive osteoporotic postmenopausal women.
Who should not take Evista?
Women who have or have had blood clots 99 in the legs, lungs, or eyes should not take EVISTA. 100 • Women who have had a heart attack or are at risk for a heart attack may have an 101 increased risk of dying from stroke when taking EVISTA.
How long can you stay on raloxifene?
Background: Due to the chronic nature of osteoporosis and the risk of invasive breast cancer, raloxifene 60 mg/day (raloxifene) is intended to be used for long-term treatment ( treatment >3 years ).
Does raloxifene make you gain weight?
Raloxifene is associated with significantly less vaginal discharge and severe hot flashes than tamoxifen in women with early breast cancer. Although weight gain of >10 pounds may also occur less frequently on this drug, this may be confounded by the shorter average duration of raloxifene therapy.
Does raloxifene affect immune system?
These data suggest that raloxifene and tamoxifen may decrease the strength of immune responses in vivo through modulation of DC differentiation and activation.
Is raloxifene a chemo drug?
Raloxifene – Chemotherapy Drugs – Chemocare.
Does raloxifene increase bone density?
Conclusions. Daily therapy with raloxifene increases bone mineral density , lowers serum concentrations of total and low-density lipoprotein cholesterol, and does not stimulate the endometrium.
What is the best time of day to take raloxifene?
You can take raloxifene at whatever time of day you find easiest to remember but try to take your doses at the same time of day, each day. This will help you to remember to take your doses regularly. You can take the tablet either before or after a meal. If you forget to take a dose, take it as soon as you remember.
Does raloxifene cause joint pain?
swelling in your hands, feet, or ankles; joint pain; flu symptoms; or. increased sweating.
Can raloxifene cause fatigue?
Many premenopausal women have menopausal side effects while taking hormonal therapy , such as hot flashes, which can disrupt your sleep and lead to fatigue. Hormonal therapies include: tamoxifen. Evista (chemical name: raloxifene)
How long should you stay on Evista?
In the STAR trial, women took Evista for 5 years . Depending on your unique situation, your doctor may recommend that you take Evista for a longer or shorter amount of time.
What happens when you stop raloxifene?
Remaining still for a long time may increase the chance that you will develop a blood clot . Your doctor will probably tell you to stop taking raloxifene at least three days before a scheduled surgery and not to take the medication if you require an extended period of bed rest for any reason.
What happens if you stop taking Evista?
Patients should stop taking EVISTA and call their doctor if they have leg pain or warmth , swelling of the legs, hands or feet, chest pain, shortness of breath or a sudden vision change, as these may be signs of a blood clot. Being unable to move around for long periods may increase this risk.
