Bence Jones proteins are not normally found in urine, so a positive test indicates that you probably have multiple myeloma . Other kinds of cancer may also be associated with a positive result. An abnormal test may indicate other types of cancer including lymphoma, chronic lymphocytic leukemia, and macroglobulinemia.
Which of the following test confirms the presence of Bence Jones proteinuria?
Detection of Bence-Jones proteinuria requires sophisticated tests such as urine protein electrophoresis , immunoelectrophoresis, and immunofixation electrophoresis. The screening test most commonly used is urine protein electrophoresis.
How is Bence Jones protein detected?
Although the heat test for Bence Jones proteins is a useful clinical test, one must be aware of both false-positive and false-negative results. Electrophoresis and immunoelectrophoresis of concentrated urine are the methods of choice for detection of a monoclonal light chain in the urine.
What is the most definitive test to confirm a diagnosis of multiple myeloma?
The complete blood count (CBC) is a test that measures the levels of red cells, white cells, and platelets in the blood. If there are too many myeloma cells in the bone marrow, some of these blood cell levels can be low. The most common finding is a low red blood cell count (anemia).
How do you collect a urine sample for Bence Jones protein?
You give a sample of your urine in a pot to your doctor or nurse . The sample is sent to the laboratory for tests. Occasionally your doctor might need to collect your urine over a 24 hour period. You’ll need to take a container home to collect your urine.
How long does it take to get Bence Jones test results?
It can take anywhere from a few days to two weeks to get your results, depending on the lab and your doctor. Bence Jones proteins are not normally found in urine, so a positive test indicates that you probably have multiple myeloma. Other kinds of cancer may also be associated with a positive result.
When should you suspect multiple myeloma?
19 Multiple myeloma should be considered as a diagnosis in patients over 50 years of age with back pain persisting more than one month if one or more red flags (Table 1) are identified.
Which protein test does not detect Bence Jones?
Healthy urine does not contain Bence Jones protein, so its presence is an indication of a health problem. Other names for this test include urine protein electrophoresis (UPEP), urine immunofixation electrophoresis, or immunoassay for free light chains.
How does a person get multiple myeloma?
What causes multiple myeloma? The exact cause of multiple myeloma is unknown . However, it starts with one abnormal plasma cell that rapidly multiplies in the bone marrow many more times than it should. The resulting cancerous myeloma cells don’t have a normal life cycle.
What is the longest survival rate for myeloma?
- Stage 1: 62 months, which is approximately five years.
- Stage 2: 44 months, which is approximately three to four years.
- Stage 3: 29 months, which is approximately two to three years.
Where does multiple myeloma start?
Doctors know that myeloma begins with one abnormal plasma cell in your bone marrow — the soft, blood-producing tissue that fills in the center of most of your bones. The abnormal cell multiplies rapidly.
Can myeloma be misdiagnosed?
Since multiple myeloma symptoms can be mistaken for other ailments , and in some cases, symptoms may not be present at all, it’s important to know the warning signs and what can put you at risk of developing the disease.
What does it mean if I have Bence-Jones protein in my urine?
The Bence-Jones protein urine test is used most often to diagnose and check on multiple myeloma , a type of cancer. Or an abnormal Bence-Jones test result may mean you have a type of malignant lymphoma. These are cancers of the lymphatic system. Multiple myeloma is a type of blood cancer that affects plasma cells.
Can Bence-Jones protein in urine mean?
Bence-Jones proteins are rarely found in urine . If they are, it is usually associated with multiple myeloma. An abnormal result may also be due to: An abnormal buildup of proteins in tissues and organs (amyloidosis)
Does multiple myeloma cause foamy urine?
Multiple myeloma, specifically – a type of cancer that forms in the plasma cells of your blood – can lead to extra protein in the urine (and cause it to look foamy).
Does myeloma show in blood tests?
For myeloma, you have blood tests and urine tests looking for an abnormal protein (the myeloma protein is called monoclonal protein, M-protein or paraprotein). Your blood sample is sent to the laboratory. A blood doctor looks at your sample under a microscope.
