Disintegration is defined as that state in which no residue of the unit under test remains on the screen of the apparatus or, if a residue remains, it consists of fragments of disintegrated parts of tablets component parts such as insoluble coating of the tablets or of capsule shells, or of any melted fatty substance ...
What is the principle of disintegration test?
Disintegration testing measures the ability of a tablet to break down into smaller particles or granules to allow the active drug to be absorbed into the body .
What is disintegration time?
Disintegration time is the time required for a dosage form to break up in to granules of specified size (or smaller) under carefully specified conditions . ... In other words DT (disintegration time) is measuring the break down of a dosage form and dissolution is measuring the drug being solubilized in the media.
What is drug disintegration?
Disintegration is a process of breaking down a substance into tiny fragments to improve its solubility in a solvent . The process is used predominantly in pharmaceutical and chemical industries. ... Dissolution is also used predominantly in pharmaceutical industries to check how soluble a drug is in the body.
Why is the disintegration of a tablet important?
Why do we do it? Like dissolution testing, Disintegration is often a pharmacopoeial testing requirement for the vast majority of solid dosage forms. It provides critical safety data on drug bioavailability in the body without having to utilise in vivo methods.
Which apparatus is used for disintegration test?
Disintegration Tester is a solid state instrument designed for the accurate estimation of disintegration time of tablets as per IP/USP standards. The instrument is designed to test two batches of six tablets, simultaneously. The unit is extremely useful for pharmaceutical industries.
What are the factors which affects disintegration of tablets?
Binders, lubricants, and hardness were found to differ in their effects on disintegration, and these factors are discussed. One two-factor interaction was found and shown to be due to a greater effect of hardness on tablets made with gelatin binder.
Which tablet has longer disintegration?
Which tablets have longer Disintegration time? Explanation: Disintegration time is the time taken by the capsule to disintegrate into smaller particles. Enteric coated tablets are coated to protect the drug from the acidic environment of the stomach. Sugar coated ones have long DT.
What is the disintegration time for coated tablet?
uncoated tablets pass the test if each of the six uncoated tablets disintegrates 3 in not more that 45 minutes; plain coated tablets pass the test if each of the six plain coated tablets disintegrates in not more than 60 minutes .
Why friability test is done?
Friability testing is a laboratory technique used by the pharmaceutical industry to test the durability of tablets during transit . ... The result is inspected for broken tablets, and the percentage of tablet mass lost through chipping.
What the body does to drug?
Pharmacokinetics , sometimes described as what the body does to a drug, refers to the movement of drug into, through, and out of the body—the time course of its absorption.
How do you increase disintegration time?
A reduction of the tablet disintegration time was obtained by means of an increase of the granulation moisture; by an increase of the fine fraction ; or by a reduction of the lubricant concentration or the compression force.
Why water is used in disintegration test?
The most important use of water is the preparation of the dissolution media , but it is also used for washing and rinsing the vessels, as well as in the thermostatic bath. ... The purity of the water used in preparing the dissolution media is important since it is in direct contact with the drug product being tested.
What is the use of disintegration apparatus?
Disintegration testers are used to test how a drug in pellet form will disintegrate in solution . Like dissolution testers, they permit researchers and medical practitioners to analyze the in vitro breakdown of powdered compounds for quality control purposes.
What is leak test apparatus?
Leak Test Apparatus is a solid state instrument designed for the leakage testing of food, drug and other industrial chemical products . The instrument is used to test the quality of packing processes in strips, blisters and sachets containing tablets, granulates and liquids.
What is the disintegration time of tablet as per IP?
Dispersible tablets are uncoated tablets or film-coated tablets intended to be dispersed in water before administration giving a homogeneous dispersion. Dispersible tablets disintegrate within 3 minutes when examined by 5.3 Disintegration test for tablets and capsules, but using water R at 15–25° C.
