A popular mineralocorticoid formulation is injectable desoxycorticosterone pivalate (DOCP); this medication can be given as an injection
every 21 to 30 days
.
What is a DOCP injection for dogs?
Desoxycorticosterone pivalate; also known as DOCP (brand names: Percorten®-V or Zycortal®), is
an injectable medication approved by the FDA for treatment of Addison’s disease in dogs
. It is injected every 3–4 weeks, depending on the patient, and replaces the missing mineralocorticoid aldosterone.
How often should Zycortal be given?
To transfer a dog from fludrocortisone to Zycortal, the authors have suggested the following protocol Day 1: Inject Zycortal at 2.2 mg/kg by subcutaneous injection
once every 25 to 31 days
and give the dog’s usual dose of fludrocortisone Day 2: Give the dog one half of the usual dose of fludrocortisone.
How long does it take Percorten to work?
It is effective and effects can usually be seen within
24 to 48 hours
. Improves life quality & expectancy in dogs & cats with Addison’s disease. Helps prevent electrolyte disturbances. Long-acting injection.
How does DOCP injection work?
DOCP
replaces a hormone that regulates sodium and potassium balance, promotes improved cardiac functioning and blood flow to the kidneys, and helps maintain the body’s blood pressure and fluid balance
. DOCP injections are given into a muscle (intramuscularly).
Does Addison’s disease shorten a dog’s life?
Addison’s disease, scientifically known as hypoadrenocorticism, is a disease with serious consequences for dogs, although fortunately with proper treatment,
dogs diagnosed with Addison’s disease are expected to have normal lifespans
.
Is Percorten the same as DOCP?
KEY POINTS. Although desoxycorticosterone pivalate (DOCP) (as Percorten-V or Zycortal) carries a label dose of 2.2 mg/kg, the evidence suggests that lower-than-label doses, particularly for large breed dogs, may be equally effective.
How much does it cost to Percorten a dog?
**The initial starting dose of Percorten-V is 1 mg/lb intramuscular injection every 25 days. For most dogs, a dose range of
0.75 mg/lb to 1.0 mg/lb (1.65 mg/kg to 2.2 mg/kg) given every 21 to 30 days
is effective.
Is Addison’s disease in dogs expensive to treat?
Medical treatment can be
as low as $50 a month or as high as $200
, depending on the dog’s response to treatment and the drug(s) selected. Frequent lab work must also be factored in to the cost structure to ensure that patients are responding appropriately.
Is Zycortal a DOCP?
Zycortal is a 25 mg/ml suspension for subcutaneous injection for dogs,
containing the active substance desoxycortone pivalate (DOCP)
. The proposed indication is for use as replacement therapy for mineralocorticoid deficiency in dogs with primary hypoadrenocorticism (Addison’s disease).
How long does Zycortal last?
After subcutaneous administration of 11 mg/kg body weight (five times the labeled starting/initial dose of 2.2 mg/kg) of ZYCORTAL Suspension, the plasma half-life (mean ± standard deviation) is approximately
17 ± 7 days
, with a maximum concentration (Cmax) of 13.2 ± 5 ng/mL, and time to maximum concentration (Tmax) of …
Can a dog overdose on Zycortal?
There is no specific antidote.
In case of signs of overdose, the dog should be treated symptomatically, and subsequent doses reduced
. Incompatibilities: In the absence of compatibility studies, this veterinary medicinal product must not be mixed with other veterinary medicinal products.
How is Percorten given?
Percorten-V is given
under the skin (subcutaneously) or into the muscle (intramuscularly) every 20 to 30 days
.
Can Percorten be given subcutaneously?
Although Percorten-V is labelled for IM injection only,
it is also used off-label for subcutaneous (SC) injection
(McCabe et al, 1995).
How do you inject Percorten?
Can dogs get Addisons disease?
Any dog regardless of age or breed can develop Addison’s Disease
however the condition is most often seen in young to middle-aged female dogs, and the following breeds: Nova Scotia duck tolling retrievers, Leonbergers, labrador retrievers, Portuguese water dogs, bearded collies, and standard poodles.
What is Fludrocort used for?
Fludrocortisone, a corticosteroid, is used
to help control the amount of sodium and fluids in your body
. It is used to treat Addison’s disease and syndromes where excessive amounts of sodium are lost in the urine. It works by decreasing the amount of sodium that is lost (excreted) in your urine.
Is Zycortal the same as Percorten?
They differ in their use of preservative and surfactant
. Percorten-V is labeled for intramuscular injection but is often given subcutaneously in clinical practice. Zycortal is labeled for subcutaneous injection.
How long can a dog live with Addisons?
Fortunately, dogs usually feel better within several days of treatment, and most symptoms of Addison’s disease are gone within
two to four weeks
. The majority of patients have a good prognosis and once they’ve been stabilized with the appropriate medications, most dogs resume normal lives.
How long can a dogs live with untreated Addison’s?
Left untreated, Addison’s disease is
often fatal
, but fortunately, with treatment, most dogs have a good outlook and can live a relatively normal life. Addison’s disease can affect any dog, of any age, but is most common in middle-aged females.
Why do Addison’s dogs shake?
Toxicity – Exposure to many toxic substances including chocolate, nicotine, and snail bait may cause trembling or shaking. Addison’s Syndrome –
Dogs that have Addison’s disease have a problem with their adrenal glands that does not allow them to have enough natural cortisol in their bloodstream
.
What is Percorten used for in dogs?
Percorten-V is a prescription medication that is commonly used by veterinarians in dogs for the
treatment of Addison’s disease
. Percorten-V is a corticosteroid used to treat conditions, such as Addison’s disease, in which the body does not produce enough of its own steroids.
What are the side effects of prednisone in dogs?
- Increased thirst and appetite.
- Frequent urination.
- Panting.
- Lethargy.
- Development or worsening of infections (especially bacterial skin infections)
- Vomiting or nausea
7
How does Zycortal work?
How does Zycortal work? Desoxycortone pivalate is a synthetically produced steroid hormone very similar to the natural hormone aldosterone.
It works in the same way as aldosterone to retain sufficient water in the body (by retaining sodium and eliminating potassium)
.
Why is there a Percorten shortage?
“Elanco is experiencing a delay in production of Percorten-V due to the
inability of our contract manufacturing facility to supply product
,” according to the company’s website. “While we work diligently to resolve this delay, there is an interruption of product supply to veterinarians.
