The two summary statistics commonly used for meta-analysis of continuous data are
the mean difference (MD) and the standardized mean difference (SMD)
. Other options are available, such as the ratio of means (see Chapter 6, Section 6.5.
What data do I need for a meta analysis?
For us to do a meta-analysis, we must have more than one study which has estimated the effect of an intervention or of a risk factor. … We need
outcome variables
in the different studies which we can somehow get in to a common format, so that they can be combined. Finally, the necessary data must be available.
How many sources do you need for a meta-analysis?
Theoretically,
only 2 studies are needed
for a meta-analysis, but it may be hard to get published. There’s a balance between the novelty and the generality of your findings. If you’re doing something very very specific, it may not be applicable to a wide group of readers.
Do you need odds ratio for meta-analysis?
A ratio of
1 indicates no difference
—that is, the outcome is just as likely to occur in the treatment group as it is in the control group. As in all estimates of treatment effect, odds ratios or relative risks reported in meta-analysis should be accompanied by confidence intervals.
Can SPSS do meta-analysis?
SPSS can be used to make a meta-analysis
but is not the most appropriate software for this task. There are software created for this specific purpose.
How are studies weighted in meta-analysis?
The usual statistical method for combining results of multiple studies is to
weight studies by the amount of information they contribute
(more specifically, by the inverse variances of their effect estimates). This gives studies with more precise results (narrower confidence intervals) more weight.
Is meta-analysis qualitative or quantitative?
Meta-analysis is a
quantitative method
that uses and synthesizes data from multiple individual studies to arrive at one or more conclusions. Meta-synthesis is another method that analyzes and combines data from multiple qualitative studies.
What is sample size in meta-analysis?
The effective sample size for a particular treatment comparison can be interpreted as
the number of patients in a pairwise meta-analysis
that would provide the same degree and strength of evidence as that which is provided in the indirect comparison or network meta-analysis.
Can you do a meta-analysis without a systematic review?
A meta-analysis is a statistical procedure for combining numerical data from multiple separate studies.
A meta-analysis should only ever be conducted in the context of a systematic review
.
How long does it take to do a meta-analysis?
They estimated it should take from
25 to 2,518 hours
, with a mean total of 1,139 hours, to conduct a meta-analysis. Their estimate included 588 hours needed for search, retrieval, and creation of a database for the search results. At the low end of the time spectrum, Saleh et al.
What data is needed for forest plot?
Additional data to the forest plot are (1) n, (2) mean and standard deviation, (3) P of each primary study, (4)
meta-analysis overall 95% confidence interval
, and (5) heterogeneity test result (with statistical significance level).
What is a forest plot in a meta analysis?
A forest plot, also known as a blobbogram, is
a graphical display of estimated results from a number of scientific studies addressing the same question, along with the overall results
. … The overall meta-analysed measure of effect is often represented on the plot as a dashed vertical line.
What data do I need to make a forest plot?
- Create a clustered bar. First, highlight the first two columns containing the study name and the effect size. …
- Add in the row positions. …
- Add a scatter plot to your graph. …
- Remove the clustered bar graph. …
- Add error bars (whiskers) to the scatter points. …
- Format the forest plot.
What does an odds ratio of 3.0 mean?
Risk Ratio vs Odds Ratio
A RR of 3 means the risk of an outcome is increased threefold. A RR of 0.5 means the risk is cut in half. But an OR of 3 doesn’t mean the risk is threefold; rather
the odds is threefold greater
.
Is a higher odds ratio better?
Greater than 1.0
indicates that the odds of exposure among case-patients are greater than the odds of exposure among controls. … For example, an odds ratio of 1.2 is above 1.0, but is not a strong association. An odds ratio of 10 suggests a stronger association.
Can you combine odds ratios?
You can combine
those odds ratio if both studies consider the same outcome
. … The prevalence odds ratio (POR) is calculated in the same way as the odds ratio (OR). So it is ok to pool these two.
What is an example of meta-analysis?
For example, a systematic review will focus specifically on the relationship between
cervical cancer and long-term use of oral contraceptives
, while a narrative review may be about cervical cancer. Meta-analyses are quantitative and more rigorous than both types of reviews.
What does K stand for in meta-analysis?
| ε Sampling error. F | g Small sample bias-corrected standardized mean difference (Hedges’ g ). I2 | ∫f(x)dx Integral of f(x) . k,K | κ True effect of an effect size cluster. MD , SMD | ̄x Arithmetic mean (based on an observed sample), identical to m . μ,m |
Is Cochrane review a meta-analysis?
What is a meta-analysis? If the results of the individual studies are combined to produce an overall statistic, this is usually called a meta-analysis. Many
Cochrane Reviews measure benefits and harms by collecting data from more than one trial
, and combining them to generate an average result.
What is a meta-analysis model?
In a random-effects meta-analysis model,
the effect sizes in the studies that actually were performed are assumed to represent a random sample from a particular distribution of these effect sizes
(hence the term random effects).
What is weighted mean difference in meta-analysis?
Weighted mean difference –
The average value after pooling results of individual studies
. The contribution of each study to the mean difference is weighted by sample size.
What is weighted effect size?
Effect sizes, on the other hand, are ‘weighted’
according to the number of participants in a study
. For instance, a study with 10 participants might have had a big effect size (such as 0.8); while another study of the same intervention may have had 1000 participants but a small effect size (such as 0.2).
Can you do meta-analysis on qualitative data?
Qualitative meta-analysis is an attempt to conduct a
rigorous secondary qualitative analysis of primary qualitative findings
. Its purpose*to provide a more comprehensive description of a phenomenon and an assessment of the influence of the method of investigation on findings*is discussed.
What is meta-analysis PDF?
Meta-analysis is
a quantitative technique that uses specific measures
(e.g., an effect size) to indicate the strength of variable relationships for the studies included in the analysis. The technique emphasizes results across multiple studies as opposed to results from a single investigation.
What is meta-analysis PPT?
1. META ANALYSIS – AN OVERVIEW Tulasi Raman P. DEFINITION Meta-analysis is
a quantitative approach for systematically combining results of previous research to arrive at conclusions about the body of research
.
How many studies do you need a primer on statistical power for meta-analysis?
Statistically speaking, only
two
values are needed to calculate an arithmetic mean. In the same vein, only two studies are needed to conduct a meta-analysis (more precisely, only two effect sizes or two p-values are needed).
What is the main difference between systematic reviews and meta-Analyses?
Systematic review or meta-analysis? A systematic review answers a
defined research question by collecting and summarizing all empirical evidence that fits pre-specified eligibility criteria
. A meta-analysis is the use of statistical methods to summarize the results of these studies.
How do you write a meta-analysis paper?
- Develop a research question.
- Define inclusion and exclusion criteria.
- Locate studies.
- Select studies.
- Assess study quality.
- Extract data.
- Conduct a critical appraisal of the selected studies.
- Step 8: Synthesize data.
When should you not do a meta-analysis?
Meta-analyses of studies that are
at risk of bias
may be seriously misleading. If bias is present in each (or some) of the individual studies, meta-analysis will simply compound the errors, and produce a ‘wrong’ result that may be interpreted as having more credibility.
How do you calculate statistical power for a meta-analysis?
This is probably due to the fact that there is no accessible software or R script to calculate meta-analytic power, like
G*Power
or the “pwr” R package, which are great options for calculating statistical power for primary research.
How many studies do you need ?: A primer on statistical power for meta-analysis?
The authors conclude that, in principle, only
two studies
are necessary to justify a meta-analysis. Thus, researchers should feel encouraged to conduct a meta-analysis, even when there are only a few primary studies. However, statistical power should be considered in the interpretation of meta-analytic results.
Is it hard to do meta-analysis?
In summary, a meta-analysis is an
important and valuable tool for summarizing data from multiple studies
. However, it is not an easy task and requires careful thought and planning to provide accurate and useful information.
How do you know if a meta-analysis is good?
The results of a meta-analysis, even if they are statistically significant, must have utility in clinical practice or constitute a message for researchers in the planning of future studies. The
results must have external validity or generalizability
and must impact the care of an individual patient.
What is the most common trap people fall into with meta-analysis?
2.
Don
‘t lose sight of what data is not in the meta-analysis. This is probably the most common trap people fall into with meta-analysis: not keeping in mind that they are often looking at a subset of results.
How are odds ratios calculated?
The odds ratio is calculated
by dividing the odds of the first group by the odds in the second group
. In the case of the worked example, it is the ratio of the odds of lung cancer in smokers divided by the odds of lung cancer in non-smokers: (647/622)/(2/27)=14.04.
What is the 95% CI?
The 95% confidence interval is a range of values that you can be 95% confident
contains the true mean of the population
. … For example, the probability of the population mean value being between -1.96 and +1.96 standard deviations (z-scores) from the sample mean is 95%.
What is heterogeneity in meta-analysis?
Heterogeneity in meta-analysis refers
to the variation in study outcomes between studies
. … The I2 statistic describes the percentage of variation across studies that is due to heterogeneity rather than chance (Higgins and Thompson, 2002; Higgins et al., 2003).
How do you read a meta-analysis?
To interpret a meta-analysis, the reader needs
to understand several concepts
, including effect size, heterogeneity, the model used to conduct the meta-analysis, and the forest plot, a graphical representation of the meta-analysis.
