What is it? Translational Research
takes scientific discoveries made in the laboratory
, in the clinic or out in the field and transforms them into new treatments and approaches to medical care that improve the health of the population.*
What are the 3 types of translational research?
- T1 – developing treatments and interventions.
- T2 – testing the efficacy and effectiveness of these treatments and interventions.
- T3 – dissemination and implementation research for system-wide change.
What is an example of translational research?
One prime example of translational research in human disease is
the study of cancer therapy
. Extensive cooperation between basic researchers, clinicians, and industry has generated numerous new targeted compounds with enhanced efficacy and decreased toxicity.
What is translational research vs clinical research?
Whereas basic research is looking at questions related to how nature works, translational research aims
to take what’s learned in basic research and apply
that in the development of solutions to medical problems. Clinical research, then, takes those solutions and studies them in clinical trials.
How do you identify translational research?
We use three methods to identify translational researchers: (1) participating in CCTS services and programs; (2)
self-identifying as a translational researcher
; and (3) engaging in activities that are characteristic of translational science. We find little overlap of these differently defined research groups.
What is the purpose of translational research?
Translational research seeks to produce more meaningful, applicable results that directly benefit human health. The goal of translational research is to
translate (move) basic science discoveries more quickly and efficiently into practice
.
What is the goal of translational research?
It’s called “translational” research because the goal is to
translate scientific insights into actual, practical therapeutic interventions that save peoples’ lives and improve their health
. “Translational science” refers to the study of those methods which are best at moving biomedical research foward.
How translational research is different from evidence based practice?
EBP is the actual application of evidence in practice (the “doing of” EBP), whereas translation science is the study of implementation interventions, factors, and contextual variables that effect knowledge uptake and use in practices and communities.
What are the stages of translational research?
- T
1
(Phase I and II Clinical Trials) – Integrate a basic scientific discovery into a candidate health-care application. - T
2
(Phase III Clinical Trials) – Assess the value of the application for health-care practice and develop evidence-based guidelines for using the application.
What translational means?
Definitions of translational. adjective.
of or relating to uniform movement without rotation
. Antonyms: nontranslational. of or relating to movement that is not uniform or not without rotation.
What is the difference between translational and applied research?
What is the difference between applied and translational research?
Translational research is broader than the traditional term “applied research
.” Applied research is any research that may possibly be useful for enhancing health or well-being.
Should I do basic or clinical research?
The AHA funds this type of
research
. Basic Research is a synonym for fundamental research, which is the study of life processes that are universal in their application to scientific knowledge. Clinical Research addresses important questions of normal function and disease using human subjects.
Are clinical trials considered translational research?
At the most basic level, clinical research is the testing of theory and application, while translational research facilitates
the connection between the study and its practical applications
to people. Clinical research involves studying human subjects through surveys, health services research, or clinical trials.
How does translational research collect data?
Translational research involves many
scientists and clinicians compiling multiple data types and sources
. These may include deidentified patient data, whole genome or exome sequences, specific tumor sequences, specimen records from patient blood draws, biopsies, and more.
What is T2 translational research?
For the purposes of this FOA, T2 translational research on aging is defined as
research to gather information needed to develop or evaluate methods of translating results from clinical studies into everyday clinical practice and health decision making
(e.g., adapting an efficacious intervention for application in …
What is a translational review?
Concise Translational Reviews
provide a scholarly, authoritative, and evidence-based synthesis of the literature pertaining to topics of fundamental importance to the practice of pulmonary, critical care, and sleep medicine
. While many reviews will be by invitation, unsolicited proposals are welcome.
