In the general population, the mean level of plasma VWF is 100 IU per dL, with a normal reference range
between 50 and 200 IU per dL
.
What does a low von Willebrand factor mean?
Von Willebrand disease is a lifelong bleeding disorder in which your blood doesn’t clot well. People with the disease have low levels of von Willebrand factor, a
protein that helps blood clot, or the protein doesn’t perform as it should
.
What is high von Willebrand factor?
VWF is an acute-phase reactant and may be elevated
above baseline
in association with a variety of conditions including inflammation, stress, exercise, liver disease, pregnancy or estrogen therapy. Baseline VWF levels also increase with aging.
What number is von Willebrand factor?
General information. von Willebrand factor (
factor VIII
-related antigen) is a large glycoprotein that is present in the plasma and endothelium and binds to other proteins, particularly factor VIII, preventing its rapid degradation.
Is von Willebrand factor the same as factor VIII?
VWF is a multimeric plasma protein that mediates thrombocytic adhesion to the subendothelium as well as thrombocyte aggregation. Moreover, it is a carrier protein of
Factor VIII
(FVIII). VWD type 1 is characterized by a quantitative deficiency of VWF and is the most common type of VWD.
At what age is von Willebrand disease diagnosed?
76% of men with VWD had been diagnosed by
age 10
, but 50% of women with VWD were not diagnosed until after age 12.
What is the prognosis of von Willebrand disease?
Outlook / Prognosis
Von Willebrand disease is
a lifelong condition
. For most people with the disease it doesn’t interfere with living active lives. Usually, it only needs to be addressed after a severe injury or if you need surgery.
Is von Willebrand disease considered a rare disease?
Platelet-type von Willebrand disease (PT-VWD), also known as pseudo-von Willebrand disease, is an
extremely rare genetic disorder
characterized by prolonged bleeding time.
What is the difference between hemophilia A and von Willebrand disease?
What is the difference between hemophilia and VWD? While both VWD and hemophilia are
bleeding disorders
, they are not the same disease. While VWD affects men and women equally, hemophilia is more common in men.
Can you get blood clots with von Willebrand disease?
People with von Willebrand’s disease
either lack
, or have ineffective supplies of, a substance in the blood called von Willebrand factor (vWF). This promotes clotting. People with the condition will have difficulty forming blood clots. For example, if they cut themselves, it will take longer to stop bleeding.
How is von Willebrand factor released?
von Willebrand factor (vWF) circulates in the blood in two distinct compartments. One, plasma vWF, is
synthesized and released from endothelial cells
; the second, synthesized by megakaryocytes, circulates in platelets primarily stored in the alpha granules.
What is Factor 8 called?
Factor VIII (
antihemophilic factor
) is the protein that is deficient or defective in patients with classical hemophilia and Von Willebrand syndrome. Factor VIII in plasma is thought to be associated in a complex with the highest molecular weight multimers of another glycoprotein, Von Willebrand protein.
How does von Willebrand affect Factor 8?
In Type 2N, the VWF attaches to the platelets normally. However, the VWF does not attach to another protein, Factor VIII (8), which is also needed for blood to clot. This causes
the body to remove the Factor VIII
(8) protein.
What causes elevated factor VIII levels?
Sustained rises in factor VIII are seen during
pregnancy, surgery
, chronic inflammation, malignancy, liver disease, hyperthyroidism, intravascular hemolysis, and renal disease. In most conditions, there is a concordant increase of factor VIII and vWF:Ag levels.
What does it mean if your factor VIII is high?
If your levels of factor VIII are too high, you are
likely at a higher risk for thrombosis
, which is blood clot formation in your blood vessels. In this case, your doctor may perform additional tests or prescribe anticoagulant therapy.
Why is Factor 8 important?
This binding domain is essential for coagulant activity. People with high levels of factor VIII are at
increased risk for deep vein thrombosis and pulmonary embolism
. Copper is a required cofactor for factor VIII and copper deficiency is known to increase the activity of factor VIII. >
