Hemophilia is usually
an inherited bleeding disorder in which the blood does not clot properly
. This can lead to spontaneous bleeding as well as bleeding following injuries or surgery. Blood contains many proteins called clotting factors that can help to stop bleeding.
Is hemophilia A dominant trait?
How are hemophilia A and B inherited (passed)? The gene with the instructions for making factor is found only on the sex chromosome labeled X. If the gene is faulty, the result is hemophilia
unless there is a dominant
, normal gene on a matching X chromosome. Hemophilia is a sex-linked recessive disorder.
What type of trait is hemophilia?
Hemophilia is
a sex-linked recessive disorder
. The abnormal gene responsible for hemophilia is carried on the X chromosome. Males have one X chromosome and one Y chromosome.
What is hemophilia example?
For example,
a boy has only one X chromosome
, so a boy with hemophilia has the defective gene on his sole X chromosome (and so is said to be hemizygous for hemophilia). Hemophilia is the most common X-linked genetic disease.
Is hemophilia A quantitative trait?
Hemophilia B is a
quasi-quantitative condition
with certain mutations showing phenotypic plasticity.
Why females are not affected by haemophilia?
“Growing up, we understood that men had hemophilia and women were “carriers.” Women passed along the X-linked gene, but did not actually get hemophilia
because (it was believed) that the “good X chromosome” compensated for the X chromosome that carried hemophilia
.
Can hemophilia be cured?
There is currently no cure for hemophilia
. Effective treatments do exist, but they are expensive and involve lifelong injections several times per week to prevent bleeding.
Which type of hemophilia is more severe?
Hemophilia A
affects 1 in 5,000 to 10,000 males. Hemophilia B is less common, affecting 1 in 25,000 to 30,000 males. Around 60% to 70% of people with hemophilia A have the severe form of the disorder and about 15% have the moderate form. The rest have mild hemophilia.
What race is hemophilia most common in?
The average age of persons with hemophilia in the United States is 23.5 years. Compared to the distribution of race and ethnicity in the U.S. population,
white race
is more common, Hispanic ethnicity is equally common, while black race and Asian ancestry are less common among persons with hemophilia.
Can males pass on hemophilia?
Thus,
males can have a disease like hemophilia if they inherit an affected X chromosome that has a mutation in either the factor VIII or factor IX gene
. Females can also have hemophilia, but this is much rarer.
What foods to avoid if you have hemophilia?
- large glasses of juice.
- soft drinks, energy drinks, and sweetened tea.
- heavy gravies and sauces.
- butter, shortening, or lard.
- full-fat dairy products.
- candy.
- foods containing trans fats, including fried. foods and baked goods (pastries, pizza, pie, cookies, and crackers)
What are the 3 types of hemophilia?
- Hemophilia A: Caused by a lack of the blood clotting factor VIII; approximately 85% of hemophiliacs have type A disease.
- Hemophilia B: Caused by a deficiency of factor IX.
- Hemophilia C: Some doctors use this term to refer to a lack of clotting factor XI.
Why is it called hemophilia?
The word “hemophilia” consists of a prefix ” hemo-” meaning “blood” and a suffix “-philia” meaning ” attraction to”. Thus the whole meaning of the term means
” a condition of attraction to blood”
.
Can hemophilia be inherited?
This change in a copy of the gene making factor VIII or factor IX is called a hemophilia allele. Most people who have hemophilia are born with it.
It almost always is inherited (passed down) from a parent to a child
.
Which is worse hemophilia A or B?
Recent evidence suggests that
hemophilia B is clinically less severe than hemophilia A
, highlighting the need to discuss further therapeutic options for each type of hemophilia. The study, “Haemophilia B is clinically less severe than haemophilia A: further evidence,” was published in Blood Transfusion.
Why is bleeding time normal in hemophilia?
11, 12 The bleeding time is said to be normal in hemophilia because
platelet adhesion and aggregation in response to ADP are normal
, and because the mechanism that is initiated by tissue factor in the absence of factor VIII coagulant activity can apparently generate enough thrombin to stop bleeding from the small …
