• A low rubella IgG avidity result indicates that there has been a recent primary rubella infection in the patient. Using this assay, maturation from low to intermediate/high avidity occurs >30 days after exposure/infection to rubella virus.
What if rubella IgG is positive in pregnancy?
A positive rubella IgG test result is good—it means that you
are immune to rubella and cannot get the infection
. This is the most common rubella test done. Negative: Less than 7 IU/mL IgG antibodies and less than 0.9 IgM antibodies.
What is an avidity test?
IgG avidity assays
measure the binding strength between IgG antibodies and virus that can help distinguish a primary CMV infection from a past infection
. Following primary CMV infection, IgG antibodies have low binding strength (low avidity) then over 2-4 months mature to high binding strength (high avidity).
What is rubella reactive mean?
Rubella IgG antibody can be formed following rubella infection or after rubella vaccination. A reactive result is
consistent with immune status to rubella virus
. Non-reactive and equivocal results flag as abnormal in Epic which indicates non-immune or equivocal immune status to rubella.
Why is rubella test done during pregnancy?
The IgG rubella test is ordered when a woman is pregnant or is planning on becoming pregnant. It is ordered
whenever a check for immunity against rubella is required
. IgM and IgG rubella tests may be ordered when a pregnant woman has signs and symptoms that may indicate a rubella infection.
Is high avidity good?
High or intermediate avidity
indicates a low risk of congenital infection
, whereas low avidity indicates an increased risk. If the result indicates low avidity, the patient should be counseled that vertical transmission is not a foregone conclusion, and additional procedures can be employed to identify fetal infection.
What does it mean if IgG is positive?
The presence of IgG suggests that the infection happened weeks to months in the past. It also suggests that you may no longer be infectious. IgG indicates that
you may have some immunity to the virus, though you may not
.
What does it mean if rubella IgG is high?
Here’s how your IgG test results stack up: A positive test is 1.0 or higher. That means you
have rubella antibodies in your blood and are immune to future infection
. A negative test is 0.7 or lower.
Can rubella cause miscarriage?
Rubella is very dangerous for pregnant women and their developing babies.
If a pregnant woman is infected with rubella, she can pass the virus to her baby
, which can lead to a miscarriage or an infant born with the congenital rubella syndrome (CRS).
What is the normal range of rubella IgG in pregnancy?
Results: Quantitative analysis of the IgG levels showed noticeable variability that ranged between
24-143 IU/ml
(average 94). One hundred and forty-five (91%) out of 160 women had rubella IgG levels of above 50 IU/ml with a range of 54-143 IU/ml (average 92) while 15 (9%) had a level between 24-46 IU/ml (average 38).
What happens if rubella is high?
Women who are infected with rubella may feel
arthritis
in their fingers, wrists and knees. This complication is rare in men or children who get rubella. In rare cases, rubella can cause serious problems, including brain infections and bleeding problems.
How does rubella affect pregnancy?
Pregnant women who contract rubella are at risk for miscarriage or stillbirth, and their developing babies are at risk for
severe birth defects
with devastating, lifelong consequences. CRS can affect almost everything in the developing baby’s body. The most common birth defects from CRS can include: Deafness.
How can I check my rubella status?
So doctors usually confirm rubella with the help of laboratory tests. You may have a
virus culture or a blood test
, which can detect the presence of different types of rubella antibodies in your blood. These antibodies indicate whether you’ve had a recent or past infection or a rubella vaccine.
How can rubella be prevented?
Rubella can be prevented
with MMR vaccine
. This protects against three diseases: measles, mumps, and rubella. CDC recommends children get two doses of MMR vaccine, starting with the first dose at 12 through 15 months of age, and the second dose at 4 through 6 years of age.
What is the name of the virus that causes rubella?
In kids, rubella — commonly called German measles or 3-day measles — is usually a mild illness. But the infection is dangerous for pregnant women because it can cause serious health problems in their babies. Rubella is caused by
the rubella (roo-BELL-uh) virus
(not the same virus that causes measles).
Is CMV the same as HPV?
Human papillomavirus (HPV) and
cytomegalovirus (CMV)
are DNA viruses that cause serious health conditions in patients of all ages. HPV is one of the most common sexually transmitted viruses causing genital infections and cancers. CMV is an opportunistic pathogen affecting immunocompromised patients.
