Briefly, the principle of clinical equipoise
What is equipoise and why is it important?
Clinical equipoise, also known as the principle of equipoise,
provides the ethical basis for medical research that involves assigning patients to different treatment arms of a clinical trial
. … This applies also for off-label treatments performed before or during their required clinical trials.
What is the principle of clinical equipoise?
Clinical equipoise is the
assumption that there is not one ‘better’ intervention present (for either the control or experimental group) during the design of a
randomized controlled trial (RCT). A true state of equipoise exists when one has no good basis for a choice between two or more care options.
Why is equipoise important to bioethics?
The equipoise requirement
ensures that trials are conducted only when expert clinicians disagree about the relative merits of standard care
and the investigational or control treatment, meaning that all treatments in a trial are consistent with competent clinical care.
What is equipoise in research ethics?
The principle of equipoise states that,
when there is uncertainty or conflicting expert opinion about the relative merits of diagnostic, prevention, or treatment options
, allocating interventions to individuals in a manner that allows the generation of new knowledge (eg, randomization) is ethically permissible.
What is equipoise in clinical trial?
The ethics of clinical research requires equipoise–
a state of genuine uncertainty on the part of the clinical investigator regarding
the comparative therapeutic merits of each arm in a trial.
How is clinical equipoise determined?
9.6.
Clinical equipoise exists when the overall benefit or harm offered by the treatment to a patient is uncertain. Clinical equipoise requires
ethical conduct when performing clinical trials
that involve assigning patients to different treatment arms.
What is equipoise according to Freedman?
Equipoise is traditionally defined as
a state of genuine uncertainty on the relative value of 2 approaches being compared in a trial
. … Freedman convincingly argued that the requirement for uncertainty on the part of each investigator (which he named theoretical equipoise) was impractical and even improbable.
How do you use equipoise in a sentence?
- As she stacked the cans into a pyramid, the stocker was precise in order to ensure equipoise and stop the cans from crashing down.
- Losing her equipoise seemed to always be a problem as her inner ear infection worsened without treatment.
What is equipoise used for?
Equipoise (Boldenone Undecylenate Injection) is recommended as an
aid for treating debilitated horses when an improvement in weight, haircoat or general physical condition is desired
. Debilitation often follows disease or may occur following overwork and overexertion.
Does boldenone increase testosterone?
Boldenone is an anabolic androgenic steroid and synthetic derivative of testosterone that was originally developed for veterinary use but has since become one of the more common performance-enhancing drugs that athletes test positive for in sport.
What is the difference between theoretical and clinical equipoise?
The primary difference between theoretical equipoise and clinical equipoise is that
the former requires the physician–researcher to be in a state of uncertainty during all stages of an RCT
, whereas the latter requires uncertainty within the expert clinical community.
What is Nonmaleficence in healthcare?
Nonmaleficence. Nonmaleficence is
the obligation of a physician not to harm the patient
. This simply stated principle supports several moral rules – do not kill, do not cause pain or suffering, do not incapacitate, do not cause offense, and do not deprive others of the goods of life.
Which of the following most accurately describes clinical equipoise?
The statement which accurately describes clinical equipoise is:
Scientific uncertainty that one study intervention is superior to another.
What is a clinical trial study?
Clinical Trials
In a clinical trial,
participants receive specific interventions according to the research plan or protocol created by the investigators
. These interventions may be medical products, such as drugs or devices; procedures; or changes to participants’ behavior, such as diet.
What is one solution to the dilemma of clinical equipoise?
Informed consent should be obtained using reasonably understood language. What is one solution to the dilemma of clinical equipoise? The basic concept of clinical equipoise is
that clinicians have an ethical responsibility to provide the best possible treatment for their patients
.
