Therapy-related factors identified include:
route of administration
, treatment complexity, duration of treatment period, medication side effects, degree of behavioral change required, taste of medication and requirement for drug storage (Table 4).
What are 3 risk factors that can cause a decrease in medication effectiveness?
Negative lifestyle factors such as
excess weight, smoking, physical inactivity, and binge drinking
can affect the health of patients taking certain medications.
Which factors may influence the therapeutic effect of a drug?
- Type of drug.
- Quantity of drug used.
- Method of drug use.
- Time taken to consume.
- Tolerance.
- Gender, size and amount of muscle.
- Use of other psycho-active drugs.
- Mood or attitude.
What are three factors that influence drug response?
Drug response can be impacted by several factors including
diet, comorbidities, age, weight, drug–drug interactions, and genetics
. Individual genetic variation in key genes involved in the metabolism, transport, or drug target can contribute to risk of adverse events
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or treatment failure.
What are the 3 types of drug interactions?
Drug interactions can be categorised into 3 groups:
Interactions of drugs with other drugs
(drug-drug interactions), Drugs with food (drug-food interactions) Drug with disease condition (drug-disease interactions).
What factors can affect drug metabolism in an elderly?
Aging results in a number of significant changes in the human liver including
reductions in liver blood flow, size, drug-metabolizing enzyme content
, and pseudocapillarization. Drug metabolism is also influenced by comorbid disease, frailty, concomitant medicines, and (epi)genetics.
How does weight affect drug effectiveness?
“In patients with extra body weight,
the drugs may not get to those optimal levels
, as there is more body mass for the drug to saturate,” he explains. Other changes that result from obesity can also affect how quickly drugs are broken down or eliminated from the body.
What can decrease medication effectiveness?
- Some Things Don’t Mix Well. You may know that some medicines don’t work well together. …
- Grapefruit. …
- Milk. …
- Licorice. …
- Chocolate. …
- Iron Supplement. …
- Alcohol. …
- Coffee.
What medicines should not be taken with milk?
Dairy products such as milk, yogurt, and cheese can interfere with certain medications, including antibiotics such as
tetracycline, doxycycline, and ciprofloxacin
.
Which medicines should not be taken together?
- Dangerous duo: Tylenol and multi-symptom cold medicines. …
- Dangerous duo: Any combo of ibuprofen, naproxen, and aspirin. …
- Dangerous duo: Antihistamines and motion-sickness medications. …
- Dangerous duo: Anti-diarrheal medicine and calcium supplements. …
- Dangerous duo: St.
What organ in the body is responsible for drug and xenobiotic metabolism?
The liver
is the organ responsible for the majority of drug metabolism through the actions of the cytochrome P450 (CYP) enzyme group (Phase 1 reactions) and the enzymes of conjugation (Phase 2 reactions) [1].
Why do people vary in their response to drugs?
A person’s size and amount of fat and muscle
impact their reaction to a drug. Larger people also have larger vascular systems, meaning that a substance must travel in more blood. The higher volume of blood dilutes the drug, so its effects aren’t as strong.
How does age affect drug response?
In general drug absorption, distribution in the body, activity, metabolism and excretion can all change as a result of ageing. The older person is more likely to
experience side effects
as well as experiencing difficulty in swallowing their medication.
What are the symptoms of a drug interaction?
- skin rash.
- bruising.
- bleeding.
- swelling.
- dizziness.
- severe nausea and vomiting.
- diarrhea.
- constipation.
What is the most common type of drug interaction?
pharmacokinetic
– defined as an alteration in the absorption, distribution, metabolism or excretion of one drug by another. This is the most common type of drug interaction. pharmacodynamic – where the drug affects the action or effect of the other drug.
What is an example of a drug interaction?
A drug-drug reaction is when there’s an interaction between two or more prescription drugs. One example is the interaction between
warfarin (Coumadin)
, an anticoagulant (blood thinner), and fluconazole (Diflucan), an antifungal medication.
