What Are Examples Of Multifactorial Disorder?

by | Last updated on January 24, 2024

, , , ,
  • Birth defects such as neural tube defects and cleft palate.
  • Cancers of the breast, ovaries, bowel, prostate, and skin.
  • High blood pressure and high cholesterol.
  • Diabetes.
  • Alzheimer disease.
  • Schizophrenia.
  • Bipolar disorder.
  • Arthritis.

What are examples of single gene disorders?

Some of the more common single-gene disorders include

cystic fibrosis, hemochromatosis, Tay-Sachs, and sickle cell anemia

. Even though these diseases are primarily caused by a single gene, several different mutations can result in the same disease but with varying degrees of severity and phenotype.

Why are some disorders referred to as multifactorial?

Common medical problems such as heart disease, diabetes, and obesity do not have a single genetic cause—they are

likely associated with the effects of multiple genes in combination with lifestyle and environmental factors

. Conditions caused by many contributing factors are called complex or multifactorial disorders.

Is Hemophilia A multifactorial disorders?

Phenotypic heterogeneity of

hemophilia is multifactorial

, mainly related to F8 mutation but other factors contribute especially to coinheritance of prothrombotic genes. Inhibitor development is mainly related to F8 null mutations, but other genetic and non genetic factors could contribute.

What are multifactorial disorders?

Multifactorial diseases are

caused by a combination of the effects of multiple genes or by interactions between genes and the environment

.

How do you test for multifactorial disorders?


Predictive genetic testing

is used to detect gene mutations associated with disorders in patients not presenting signs/symptoms at the time of the testing. Multifactorial diseases are caused by complex and variable interactions between multiple genetic, environmental, and infectious factors.

Can multifactorial diseases be treated?

Although multifactorial diseases are often found gathered in families yet, they do not show any distinct pattern of inheritance.

It is difficult to study

and treat multifactorial diseases because specific factors associated with these diseases have not yet been identified.

What are the three types of single gene disorders?

Single gene disorders can be divided into different categories:

dominant

?

, recessive

?

and X-linked

.

What are the four major types of single gene disorders?

Single gene disorders- cystic fibrosis (CF)

The inheritance patterns of these disorders include

autosomal dominant, autosomal recessive, X-linked dominant, X-linked recessive, and mitochondrial

.

What is the most common genetic disorder?


Sickle cell disease

is the most common inherited blood disorder in the United States, affecting around 100,000 Americans, most commonly in African Americans. There is a 25% chance that a child will be born with sickle cell disease if both parents have the defective gene.

What are the major factors considered in multifactorial inheritance?

Multifactorial inheritance means that “many factors” (multifactorial) are involved in causing a birth defect. The factors are usually

both genetic and environmental

, where a combination of genes from both parents, in addition to unknown environmental factors, produce the trait or condition.

What are examples of multifactorial traits?

  • Birth defects such as neural tube defects and cleft palate.
  • Cancers of the breast, ovaries, bowel, prostate, and skin.
  • High blood pressure and high cholesterol.
  • Diabetes.
  • Alzheimer disease.
  • Schizophrenia.
  • Bipolar disorder.
  • Arthritis.

Is autism a multifactorial disorder?

The underlying cause of autism spectrum disorder (ASD) is generally unknown. Scientists suspect that

it is a multifactorial condition

, meaning that a variety of factors (both genetic and environmental) likely contribute to the development of the condition.

Why females are not affected by haemophilia?

“Growing up, we understood that men had hemophilia and women were “carriers.” Women passed along the X-linked gene, but did not actually get hemophilia

because (it was believed) that the “good X chromosome” compensated for the X chromosome that carried hemophilia

.

Can hemophilia be cured?


There is currently no cure for hemophilia

. Effective treatments do exist, but they are expensive and involve lifelong injections several times per week to prevent bleeding.

What race is hemophilia most common in?

The average age of persons with hemophilia in the United States is 23.5 years. Compared to the distribution of race and ethnicity in the U.S. population,

white race

is more common, Hispanic ethnicity is equally common, while black race and Asian ancestry are less common among persons with hemophilia.

James Park
Author
James Park
Dr. James Park is a medical doctor and health expert with a focus on disease prevention and wellness. He has written several publications on nutrition and fitness, and has been featured in various health magazines. Dr. Park's evidence-based approach to health will help you make informed decisions about your well-being.