The PT/
INR is prolonged by
the new direct oral anticoagulants rivaroxaban (Xarelto) and apixaban (Eliquis), and the PTT is prolonged by the direct thrombin inhibitor dabigatran (Pradaxa). Neither test is prolonged by the antiplatelet drugs
Does Plavix affect INR?
Although the administration of clopidogrel 75 mg per day did not modify the pharmacokinetics of S-warfarin (a CYP2C9 substrate) or INR in patients receiving long-term warfarin therapy, coadministration of Plavix with warfarin
increases the risk of bleeding because of independent effects on hemostasis
.
Do antiplatelet drugs affect INR?
Antiplatelet drugs which
inhibit platelet function impose additional risks for haemorrhage
by affecting primary haemostasis and further inhibition of thrombus formation. Some antiplatelet drugs may also alter warfarin metabolism and lead to an unstable INR.
Does Plavix require INR monitoring?
Clopidogrel doesn’t require regular blood test monitoring
, but it affects platelet function and bleeding times for up to 7–10 days. You may need to avoid elective dental work and elective operations while taking aspirin or clopidogrel due to risks of bleeding.
Does clopidogrel change INR?
Mean INR remained extremely stable in the clopidogrel group, the
maximum percentage change from baseline being 0.6% at Day 6
. Plasma levels of R- and S-warfarin also remained very stable in those receiving clopidogrel.
Can you drink coffee with Plavix?
These medications are used to slow blood clotting and include aspirin, clopidogrel (Plavix), ibuprofen (Advil, Motrin, and others), naproxen (Anaprox, Naprosyn, and others), enoxaparin (Lovenox), and more.
Health experts advise caution when combining them with coffee
, which can also slow blood clotting.
What is the difference between aspirin and Plavix?
Aspirin and Plavix belong to different drug classes. Aspirin is a nonsteroidal anti-inflammatory drug (NSAID) and Plavix is an
antiplatelet agent
.
What is the safest blood thinning medication?
Safer Blood-Thinning Drugs to Prevent Stroke
The newer medications are
Pradaxa (dabigatran)
, Xarelto (rivaroxaban), Eliquis (apixaban), and most recently Savaysa (edoxaban) — which work by preventing pooled blood in the heart from clotting. Unlike warfarin, the newer drugs are safer and easier for patients to use.
Can I take aspirin instead of blood thinners?
In general, aspirin is
considered to be inferior to other
blood thinners for reducing stroke risk in people with nonvalvular AFib and a CHA
2
DS
2
–VASc score of 2 or higher. When it comes to bleeding risk, aspirin is also not necessarily safer than some other blood thinners.
What is the difference between anticoagulants and blood thinners?
Anticoagulants, more commonly referred to as “blood thinners,” work
by inhibiting the clotting factors
. Antiplatelets work by inhibiting the enzymes that cause the platelets to clump together.
What can be used instead of Plavix?
Brilinta
has been marketed and studied as a more effective drug than Plavix. It has been shown to be a better drug for reducing rates of cardiovascular death and preventing heart attack or stroke.
What can you not take with Plavix?
- Tagamet (generic name: cimetidine)
- Prozac, Sarafem, and Symbyax (generic name: fluoxetine)
- Luvox (generic name: fluvoxamine)
- Ticlid (generic name: ticlopidine)
- Diflucan (generic name: fluconazole)
- Nizoral (generic name: ketoconazole)
- VFEND (generic name: voriconazole)
Which is better Plavix or Coumadin?
Coumadin (warfarin) is a cheap and effective medicine that prevents new blood clots. It requires regular blood tests and you’ll need to eat, exercise, and take your medicines consistently.
Plavix (clopidogrel)
can help lower your risk of getting a stroke or heart attack. You only need to take it once a day.
What foods should I avoid while taking clopidogrel?
Is there any food or drink I need to avoid? Do not drink
grapefruit juice
while taking clopidogrel. Grapefruit juice decreases the effects of your medicine, so that it may not work as well to prevent clots.
When is the best time to take clopidogrel?
You can take clopidogrel at whatever time of day you find easiest to remember, but take your doses at the same time of day each day. Most people prefer to take it
in the morning
, as they find this helps them to remember to take it regularly. You can take the tablet either before or after a meal.
Does clopidogrel affect blood pressure?
You likely won’t have blood pressure changes while you’re taking Plavix
. However, sudden drops in blood pressure may be a symptom of serious internal bleeding, which is a possible side effect of Plavix.
