[ sŭb′ĕn-dō-thē′lē-əl ] n.
The thin layer of connective tissue lying between the endothelium and elastic lamina in the intima of blood vessels
.
What does Subendothelial mean?
Medical Definition of subendothelial
:
situated under an endothelium subendothelial
tissues.
Where is the subendothelial space?
sub·en·do·the·li·al
(sŭb'en-dō-thē'lē-ăl),
Below the endothelium
.
What molecule on the Subendothelium is the first one bound by platelets?
Connective Tissues of the Subendothelium
The first step in the hemostatic cascade is interaction of platelets with the exposed ECM at the injured vessel. The subendothelial component responsible for platelet adhesion and aggregation is
collagen
.
What is the intima of an artery?
The
tunica intima
, the innermost layer, consists of an inner surface of smooth endothelium covered by a surface of elastic tissues. The tunica media, or middle coat, is thicker in arteries, particularly in the large arteries, and consists of smooth muscle cells intermingled with elastic fibres….
What are the layers of the blood vessels?
- The adventitia or outer layer which provides structural support and shape to the vessel.
- The tunica media or a middle layer composed of elastic and muscular tissue which regulates the internal diameter of the vessel.
What's the main artery called?
The largest artery is
the aorta
, the main high-pressure pipeline connected to the heart's left ventricle. The aorta branches into a network of smaller arteries that extend throughout the body. The arteries' smaller branches are called arterioles and capillaries.
What is intima?
the innermost membrane or lining of some organ or part
, especially that of an artery, vein, or lymphatic.
What kind of tissue prevents veins from collapsing?
The tunica externa
is often thicker in veins to prevent collapse of the blood vessel and provide protection from damage since veins may be superficially located.
What triggers platelet adhesion?
Following adhesion, platelets are activated by a number
of agonists such as adenosine diphosphate (ADP) and collagen
present at the sites of vascular injury. These agonists activate platelets by binding to specific receptors on the platelet surface discussed earlier.
What do platelets stick to?
Platelets floating by in the blood are attracted to
collagen
. They quickly move to the site of the injury. In order for the platelets to stick to the collagen, they need a “glue.” The “glue” that sticks platelets to the collagen is a protein in the blood called von Willebrand factor (VWF).
What keeps platelets from sticking to capillary walls?
Collagen
.
Endothelial cells
provide a barrier to the interaction of platelets in flowing blood with various types of collagen present in the subendothelial matrix [93].
What layer is thickest in arteries?
The wall of an artery consists of three layers. The innermost layer, the tunica intima (also called tunica interna), is simple squamous epithelium surrounded by a connective tissue basement membrane with elastic fibers. The middle layer,
the tunica media
, is primarily smooth muscle and is usually the thickest layer.
What are the 3 layers of an artery?
The inner layer is called intima, the middle layer is called media, and the outer one is denoted the adventitia
. These three layers are observable in a cross-sectional view of the artery, as shown graphically in Fig.
What is the largest artery found in the body?
The aorta
is the large artery that carries oxygen-rich blood from the left ventricle of the heart to other parts of the body.
What are the 3 types of blood vessel?
This vast system of blood vessels –
arteries, veins, and capillaries
– is over 60,000 miles long.
