Streptomycin is an aminoglycoside. It works by
blocking the ability of 30S ribosomal subunits to make proteins
, which results in bacterial death.
How does streptomycin affect translation?
During streptomycin inhibition of translation of phage mRNA
the peptidyl-tRNA is blocked in the ribosome P site
Does streptomycin interfere with bacterial translation?
Streptomycin, like other aminoglycoside antibiotics, binds to the 30S subunit of the bacterial ribosome [1], and leads initially to mistranslation, and ultimately to
a complete inhibition of translation
.
How does streptomycin work against bacteria?
Streptomycin is an aminoglycoside. It works
by blocking the ability of 30S ribosomal subunits to make proteins
, which results in bacterial death. Albert Schatz first isolated streptomycin in 1943 from Streptomyces griseus.
Which bacterial process does streptomycin inhibit?
Streptomycin is an aminoglycoside. It works by blocking the
ability of 30S ribosomal subunits to make proteins
, which results in bacterial death.
Is streptomycin an antifungal?
| ChEBI Name streptomycin | ChEBI ID CHEBI:17076 |
|---|
What infections does streptomycin treat?
What is streptomycin? Streptomycin is an antibiotic that is used to treat
moderate to severe tuberculosis, pneumonia, E. coli, influenza, plague and other infections
caused by certain bacteria.
Why is streptomycin not used?
A history of
clinically significant hypersensitivity to streptomycin
is a contraindication to its use. Clinically significant hypersensitivity to other aminoglycosides may contraindicate the use of streptomycin because of the known cross-sensitivity of patients to drugs in this class.
Why streptomycin is no longer used?
Streptomycin was the first effective antituberculosis drug but is no longer a first-line drug as
it has the disadvantage that it is not absorbed from the intestine and must therefore be given by intramuscular injection
. This raises the associated danger of transmission of HIV and other viruses by contaminated needles.
Why is streptomycin so effective?
Streptomycin is an
effective antibiotic because its structure is similar to that of the anticodons that would usually bind to the ribosome
. Streptomycin is significant because it was the first antibiotic that could treat tuberculosis. Over time, bacteria have become resistant to streptomycin.
What type of antibiotic is streptomycin?
Streptomycin belongs to a class of drugs known as
aminoglycoside antibiotics
. It works by killing the organisms that cause the infection. This drug may also be used to treat other serious infections (e.g., Mycobacterium avium complex-MAC, tularemia, endocarditis, plague) along with other medications.
What is the mechanism of streptomycin?
Streptomycin is an aminoglycoside. It
works by blocking the ability of 30S ribosomal subunits to make proteins
, which results in bacterial death.
Why do antibiotics not affect human cell translation?
Human cells do not make or need peptidoglycan
. Penicillin, one of the first antibiotics to be used widely, prevents the final cross-linking step, or transpeptidation, in assembly of this macromolecule. The result is a very fragile cell wall that bursts, killing the bacterium.
What is the most serious toxic effect of streptomycin?
Streptomycin injection is usually used for serious bacterial infections for which other medicines may not work. However, it may also cause some serious side effects, including
damage to your hearing and sense of balance
. These side effects may be more likely to occur in elderly patients and newborn infants.
Is streptomycin a penicillin?
What is Penicillin-Streptomycin? Penicillin is a
beta-lactam antibiotic
derived from Penicillium fungi. It interferes with the final stage of bacterial cell wall synthesis, the cross-linking of different peptidoglycan strands. Streptomycin is an aminoglycoside antibiotic produced by Streptomyces.
What is streptomycin effective against?
Streptomycin is an important antibiotic therapy primarily used to treat the infection from
M. tuberculosis
and other aerobic gram-negative bacteria. The MRC randomized trial of streptomycin established streptomycin as an effective therapy for pulmonary tuberculosis.
