Piperacillin/tazobactam is used to treat a
wide variety of bacterial infections
. It is a penicillin antibiotic. It works by stopping the growth of bacteria.
What kind of infections does Zosyn treat?
- a bacterial infection.
- presumed infection in neutropenic patient with fever.
- bacterial pneumonia caused by Haemophilus influenzae.
- pneumonia caused by bacteria.
- nosocomial bacterial pneumonia.
- hospital-acquired pneumonia from Staphylococcus bacteria.
What bacteria does Zosyn cover?
Piperacillin/tazobactam (Zosyn)
This antibiotic has activity against many Gram-positive, Gram-negative, and anaerobic pathogens. It covers
Streptococci, Staphylococci
(but not methicillin-resistant S. aureus [MRSA]), Hemophilus, Moraxella, Enterobacteriaceae, and Pseudomonas aeruginosa.
Who should not take Zosyn?
a significant drop in a certain type of white blood cell called a neutrophil.
chronic kidney disease
stage 3B (moderate) chronic kidney disease stage 4 (severe) chronic kidney disease stage 5 (failure)
Can Zosyn make you sleepy?
SIDE EFFECTS: Swelling, redness, pain, and soreness at the injection site may occur. Dizziness, trouble sleeping, nausea, vomiting, diarrhea, and headache may also occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.
How long can you stay on ZOSYN?
The usual total daily dosage of ZOSYN for adult patients with indications other than nosocomial pneumonia is 3.375 g every six hours [totaling 13.5 g (12.0 g piperacillin/1.5 g tazobactam)], to be administered by intravenous infusion over 30 minutes. The usual duration of ZOSYN treatment is from
7 to 10 days
.
Is ZOSYN a good antibiotic?
Piperacillin and tazobactam are penicillin antibiotics that fight bacteria in the body. Zosyn is
used to treat many different infections
caused by bacteria, such as stomach infections, skin infections, pneumonia, and severe uterine infections. Zosyn is sometimes given together with other antibiotics.
How do you know if zosyn is working?
Your doctor will check your or your child’s progress closely while you are receiving this
medicine. This will allow your doctor to see if the medicine is working properly and to decide if you should continue to receive it. Blood and urine tests may be needed to check for unwanted effects.
What bacteria does zosyn not cover?
They do NOT cover:
MRSA, VRE, Atypicals
, among others. Zosyn (Piperacillin/Tazobactam) – broader due to excellent anaerobe coverage, activity vs Amp-susceptible Enterococcus. No ESBL coverage.
What is the best antibiotic for sepsis?
| Best medications for sepsis | Vancomycin Antibiotic Intravenous injection | Rocephin (ceftriaxone) Antibiotic Intravenous injection | Zosyn (piperacillin-tazobactam) Antibiotic Intravenous injection | Cefepime Antibiotic Intravenous injection |
|---|
Is zosyn bad for kidneys?
If alternative treatment options are inadequate or unavailable, monitor renal function during treatment with Zosyn. Precautions section stating that combined use of these two drugs may be associated with an
increased incidence of acute kidney injury
.
Is zosyn a penicillin?
Piperacillin/tazobactam is used to treat a wide variety of bacterial infections. It is
a penicillin antibiotic
. It works by stopping the growth of bacteria.
Why is tazobactam added to zosyn?
Tazobactam
inhibits beta lactamase and prevents the destruction of piperacillin
. Therefore, tazobactam is given with piperacillin to enhance the activity of piperacillin in eradicating bacterial infections. Piperacillin kills bacteria by inhibiting the synthesis of bacterial cell walls.
When do you give Zosyn?
Initial presumptive treatment of patients with nosocomial pneumonia should start with ZOSYN at a dosage of
4.5 g every six hours
plus an aminoglycoside, totaling 18.0 g (16.0 g piperacillin/2.0 g tazobactam). The recommended duration of ZOSYN treatment for nosocomial pneumonia is 7 to 14 days.
Does Zosyn affect the liver?
Most cases of
liver injury
related to piperacillin are linked to the combination of piperacillin with the beta-lactamase inhibitor tazobactam (Zosyn and generics), which is more commonly used than piperacillin alone. Likelihood score: B (known rare cause of clinically apparent liver injury).
Why do you run Zosyn over 4 hours?
Summary: EI β-lactam therapy is now considered a key aspect of
antimicrobial stewardship
, and published evidence indicates that i.v. infusion of piperacillin-tazobactam over extended periods (e.g., four hours) instead of the traditionally recommended 30 minutes may offer several advantages, including reduced mortality …
