DULoxetine may cause liver damage, and taking it with
alcohol
may increase that risk. You should avoid or limit the use of alcohol while being treated with DULoxetine.
Which medications should not be taken with grapefruit?
Examples of common medications that interact with grapefruit juice include certain
statin
cholesterol drugs such as atorvastatin (Lipitor), lovastatin, simvastatin (Zocor), felodipine (Plendil) and other calcium channel blockers, clarithromycin (Biaxin), and loratadine (Claritin).
Does grapefruit interfere with Cymbalta?
Mixing Cymbalta with grapefruit or grapefruit juice may increase the risk of side effects or overdose. The
acidic fruit interferes with the metabolism of the drug
and may allow it to build up in the patient. Light drinking of alcohol does not appear to enhance duloxetine’s effects.
What happens if you eat grapefruit while on antidepressants?
Furanocoumarins disrupt the normal function of CYPs. In fact, studies show that they increase the blood levels of over 85 medications (1). By slowing the way in which CYPs normally break down medications in your gut and liver, grapefruit can
increase the side effects of
these drugs (1).
Can I take Cymbalta with orange juice?
Contact your doctor if your condition changes or you experience increased side effects. Orange juice
is not expected to interact
.
Can I have a glass of wine while taking Cymbalta?
Aside from worsening depression, drinking alcohol while taking Cymbalta
raises the risk of liver damage
. Both alcohol and Cymbalta can cause liver injury on their own. However, the risk goes up when they are taken together — especially if you have multiple drinks at a time.
Can I drink coffee with Cymbalta?
Caffeine may increase the blood levels and effects of DULoxetine. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications.
Can you have grapefruit with levothyroxine?
Grapefruit juice may slightly delay the absorption of levothyroxine, but
it seems to have only a minor effect on its bioavailability
. Accordingly, the clinical relevance of the grapefruit juice-levothyroxine interaction is likely to be small.
What happens if you eat grapefruit while taking sertraline?
Anti-anxiety medications such as sertraline (Zoloft), buspirone (Buspar), and diazepam (Valium) can
cause drowsiness or dizziness
when taken with grapefruit juice.
Is 30mg of Cymbalta effective?
For some patients, it may be desirable to start at
30 mg once daily for 1 week
, to allow patients to adjust to CYMBALTA before increasing to 60 mg once daily. While a 120 mg/day dose was shown to be effective, there is no evidence that doses greater than 60 mg/day confer any additional benefits.
What does Cymbalta do to the brain?
How Does Cymbalta Work? Cymbalta
inhibits the reuptake of serotonin and norepinephrine
in the central nervous system. It also increases dopamine by acting on dopamine reuptake pumps, thus increasing the diffusion of dopamine in the brain.
What time should I take my Cymbalta?
It is best to take duloxetine at the same time each day. Most people take it
in the morning
. If you find that you feel drowsy after taking it in the morning, try taking it in the evening.
Does Cymbalta make you not want to drink?
Common side effects of Cymbalta include headache, dizziness, diarrhea, constipation, dry mouth, decreased appetite, and drowsiness. Although Cymbalta can be used to help ease the psychological effects of alcohol withdrawal symptoms, it can cause strong alcohol cravings if it is used incorrectly.
What happens when you mix Cymbalta and alcohol?
Both alcohol and Cymbalta
can lead to liver damage
. Taking these two substances together can heighten this risk. Your liver breaks down the substances you consume and removes toxins from your body. Because alcohol contains a number of toxins, chronic use can eventually overwork your liver and lead to liver damage.
Is Cymbalta hard on the liver?
“Postmarketing reports of liver injury (including hepatitis and cholestatic jaundice) suggest that patients with pre-existing liver disease who take [Cymbalta] may have
an increased risk for further liver damage
,” says the FDA.
