Antibiotics can inhibit protein synthesis by targeting either the 30S subunit, examples of which include
spectinomycin, tetracycline
, and the aminoglycosides kanamycin and streptomycin, or to the 50S subunit, examples of which include clindamycin, chloramphenicol, linezolid, and the macrolides erythromycin, …
Which types of antibiotics inhibit protein synthesis?
- Tetracycline and glycylcycline.
- Oxazolidinones.
- Amphenicols and pleuromutilins.
- Macrolides and ketolides.
- Lincosamides.
- Streptogramins.
Which of the following antibiotics function as protein synthesis inhibitors?
Protein synthesis inhibitors represent another major group of clinically useful antibacterials, such as
erythromycin, tetracycline, chloramphenicol, and aminoglycosides
. They selectively interact with the 70S bacterial ribosome and spare the 80S eukaryotic ribosome particle.
Which of the following antibiotics inhibits protein synthesis quizlet?
All of the following antibiotics inhibit protein synthesis except:
Streptomycin
. Tetracycline.
Why do antibiotics target protein synthesis?
All of the antibiotics that target bacterial protein synthesis do
so by interacting with the bacterial ribosome and inhibiting its function
. The ribosome might not seem like a very good target for selective toxicity, because all cells, including our own, use ribosomes for protein synthesis.
Which drug inhibit protein synthesis?
INTRODUCTION. Bacteriostatic protein-synthesis inhibitors that target the ribosome, such as
tetracyclines
and gly-cylcyclines, chloramphenicol, macrolides and ketolides, lincosamides (clindamycin), streptogramins (quinupristin/dalfopristin), oxazolidinones (linezolid), and aminocyclitols (spectinomycin).
Is Penicillin a protein synthesis inhibitor?
Penicillins have been shown
to inhibit bacterial cell wall synthesis
, and interact with penicillin binding proteins, leading to bacterial lysis.
What interferes with peptidoglycan synthesis?
β-Lactam antibiotics
are bacteriocidal and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. Glycopeptide antibiotics include vancomycin, teicoplanin, telavancin, bleomycin, ramoplanin, and decaplanin.
How will you target protein synthesis using antibiotics?
It is reported that many clinically used antibiotics specifically target
bacterial ribosomes
[151], targeting different stages of bacterial protein synthesis based on their binding site in the ribosome or by binding to other protein factors associated with protein biosynthesis. …
Which of the following antibiotics prevents folate synthesis?
5.2
Trimethoprim
.
TMP
is a synthetic antibiotic that binds with the enzyme dihydrofolate reductase (DHFR) inhibiting the folic acid synthesis pathway (Brogden et al., 1982). It is widely used in the treatment of urinary tract infections and Pneumocystis jiroveci pneumonia.
Which of the following antibiotics inhibits mycolic acid synthesis?
The drugs shown to inhibit mycolic acid biosynthesis are
isoniazid, ethionamide, isoxyl, thiolactomycin, and triclosan
. In addition, pyrazinamide was shown to inhibit fatty acid synthase type I which, in turn, provides precursors for fatty acid elongation to long-chain mycolic acids by fatty acid synthase II.
Is antimicrobial the same as antifungal?
An antimicrobial is an agent that kills microorganisms or stops their growth. Antimicrobial medicines can be grouped according to the microorganisms they act primarily against. For example, antibiotics are used against bacteria, and antifungals are
used against fungi
.
How do antibiotics that affect protein synthesis work?
Some antibiotics, including tetracycline, which is used to treat acne, respiratory tract infections and other conditions, inhibit protein synthesis. The drugs do this by
preventing key molecules from binding to selected sites on cell structures called ribosomes
, where protein synthesis occurs.
What antibiotic prevents the continuation of protein synthesis?
Macrolide antibiotics
are among the most successful antibacterials and have been widely used for the treatment of serious infections. These drugs stop bacterial growth by inhibiting protein synthesis.
Where does bacterial protein synthesis occur?
Protein synthesis occurs on macromolecular machines,
called ribosomes
. Bacterial ribosomes and the translational machinery represent one of the major targets for antibiotics in the cell.
Are inhibitors of protein synthesis mechanism?
Protein synthesis inhibitors are the
substances that stops or slow the process of translation (protein synthesis)
. These inhibitors usually act at the ribosomal level. Ribosomes are the site of protein synthesis in both prokaryotes and eukaryotes.
