Boys may have had
excessive bleeding after circumcision
. Sometimes the first sign in women is that their menstrual periods are very heavy. Other symptoms of platelet disorders include tiny red dots (petechiae) on the skin and bruising after minor injuries.
What are the common causes of platelet dysfunction?
- Idiopathic thrombocytopenic purpura (bleeding disorder in which the immune system destroys platelets)
- Chronic myelogenous leukemia (blood cancer that starts inside bone marrow)
- Multiple myeloma (blood cancer that starts in the plasma cells in the bone marrow)
What are the signs and symptoms of platelet function disorders?
- Easy bruising.
- Nosebleeds.
- Heavy periods.
- Bleeding gums when baby teeth fall out.
- Bleeding into the gut.
- Excessive bleeding during surgery or after minor injuries.
What is the most common platelet disorder?
- Bernard Soulier disease.
- Glanzmann’s thrombasthenia.
- Hermansky Pudlak syndrome.
- Jacobsen syndrome.
- Lowe syndrome.
- Platelet release and storage pool defects.
- Thrombocytopenia with absent radius (TAR) syndrome.
- Thrombotic thrombocytopenic purpura (TTP)
What is the most frequent cause of acquired platelet dysfunction?
Antiplatelet drugs
are the most common cause of acquired platelet disorders leading to bleeding.
How is platelet dysfunction treated?
Treatment of Platelet Dysfunction
If platelet dysfunction is caused by a drug,
stopping the drug usually is the only treatment needed
. People with an inherited platelet disorder that causes excessive bleeding usually should not take drugs that impair platelet function.
Can stress affect platelet levels?
Research gives hint that
platelets activation and reactivity is increased by mental stress
. This leads to enhanced cross talk with the immune system via paracrine secretion, receptor interaction and formation of platelet leucocyte-aggregates.
What happens if platelets are not functioning properly?
If your platelets don’t function properly, you are at an
increased risk of bleeding
. Symptoms may include: Increased bruising. Nosebleeds.
What diseases are caused by low platelets?
- Have a blood disorder that affects your bone marrow, called aplastic anemia.
- Have cancer such as leukemia or lymphoma, which damages your bone marrow.
- Have a platelet-lowering disease like Wiskott-Aldrich or May-Hegglin syndromes.
- Have a virus such as chickenpox, mumps, rubella, HIV, or Epstein-Barr.
What is platelet dysfunction syndrome?
When platelets do not function properly, people are at risk of excessive bleeding. However, some people have disorders that cause them to bruise or bleed too easily. Sometimes people bleed without any… read more due to injuries or even spontaneous bleeding. Platelet dysfunction may be.
What drugs affect platelet count?
- Furosemide.
- Gold, used to treat arthritis.
- Nonsteroidal anti-inflammatory drugs (NSAIDs)
- Penicillin.
- Quinidine.
- Quinine.
- Ranitidine.
- Sulfonamides.
What is a normal platelet count for a woman?
What is a healthy platelet count? A normal platelet count ranges from
150,000 to 450,000 platelets per microliter of blood
. Having more than 450,000 platelets is a condition called thrombocytosis; having less than 150,000 is known as thrombocytopenia.
Does platelet count change with age?
Platelet count decreases with age
, and women have more platelets than man after puberty.
What are the qualitative platelet disorders?
Qualitative Platelet Disorder (QPD) is
a disorder effecting the structure or function of platelets
. Patients with this disorder will have an adequate number of platelets but poor “quality” of clotting.
How is platelet disorder diagnosed?
Doctors can diagnose many platelet disorders by
a simple blood test
(a complete blood count. Sometimes a blood disorder causes no symptoms but is discovered… read more [CBC]) to measure the number of platelets. Special tests may be needed to diagnose platelet dysfunction.
What does an abnormal platelet function test mean?
What does the test result mean? The interpretation of results of the various types of platelet function tests depends on why the tests were performed. In the investigation of excessive bleeding or the potential for bleeding during surgery, abnormal results
may indicate the presence of a platelet disorder
.
