ABILIFY MAINTENA
®
(aripiprazole) is a
once-monthly
* maintenance treatment for bipolar I in adults that may help keep your bipolar I symptoms stable. *You should continue to take your current bipolar I disorder medication for 2 weeks after your first treatment with ABILIFY MAINTENA.
How often do you get Abilify injection?
Aripiprazole extended-release injection (Abilify Maintena) is usually given
once every 4 weeks
. If you have never received aripiprazole previously, your doctor will tell you to take aripiprazole tablets by mouth for up to 2 weeks before you receive your first injection.
How early can Abilify Maintena be given?
The recommended starting and maintenance dose of ABILIFY MAINTENA is 400 mg monthly (
no sooner than 26 days after the previous injection
).
How long does Abilify Maintena stay in your system?
Abilify’s half-life can be used to figure out how long Abilify stays in your system. It typically takes about five half-lives for a drug to leave your system entirely. So Abilify tablets and Abilify Maintena will stay in your system for about 16 days. And Abilify Maintena will stay in your system for
about 150 days
.
Can ABILIFY MAINTENA be given in the deltoid?
When writing an electronic or conventional prescription for ABILIFY MAINTENA, remember to specify either the pre-filled, dual chamber syringe or the vial kit.
All doses can be given by gluteal or deltoid intramuscular administration
.
How long does injectable Abilify last?
| Type of medicine An antipsychotic medicine | Also called Abilify Maintena® |
|---|
What is the difference between Abilify and ABILIFY MAINTENA?
They both contain the active ingredient aripiprazole, an atypical antipsychotic, and are approved for the treatment of schizophrenia and bipolar disorder. Abilify is approved for other uses, too.
Abilify comes as an oral medication taken daily, while Abilify Maintena is a long-acting injection given every 4 weeks
.
Where do you inject ABILIFY MAINTENA?
Aripiprazole is given by injection into the
buttock or upper arm muscle
by a health care professional, usually once every month. Some doses may be given once every 6 weeks or once every 2 months. Do not rub/massage the injection site after your dose.
How do I get ABILIFY MAINTENA?
Receiving ABILIFY MAINTENA
LCCs are places where you can get your prescribed injection instead of your healthcare provider’s office. These can be
retail pharmacies, urgent care clinics, dialysis centers, and infusion centers
where a healthcare provider can give you your ABILIFY MAINTENA.
Can ABILIFY be given twice daily?
Because of the long half-life of aripiprazole,
it is administered daily although it might be administered twice-weekly
. Adverse effects are major concern for treating tic disorders with medications. Many of these adverse effects are dose dependent. For example, sedation and increased appetite are common.
How do you transition from oral ABILIFY to Maintena?
Aripiprazole long-acting-injection (Abilify Maintena, ARISTADA) [National Drug Monograph]. Typical dose: 6.25-25 mg every 2-4 weeks. General conversion formula:
For each 10 mg/day PO, give 12.5 mg decanoate every 3 weeks. Increase by 12.5 mg increments if doses >50 mg needed
.
Is ABILIFY MAINTENA Child approved?
It is not known if ABILIFY MAINTENA is safe and effective in children under 18 years of age
. *You should continue to take your current bipolar I disorder medication for 2 weeks after your first treatment with ABILIFY MAINTENA.
Can Abilify cause permanent damage?
While the most common Abilify side effects are minor, serious side effects have been reported.
Some side effects, such as tardive dyskinesia, can cause permanent injury even after a person stops taking the drug
.
What happens when you go off Abilify?
If you stop taking it suddenly,
the balance starts to change, and your old symptoms could return
. You could also experience some unpleasant withdrawal symptoms like headache, feeling sick and sleep problems. You can stop taking aripiprazole safely with your doctor’s help.
Can you drink alcohol while taking Abilify?
Alcohol can increase the nervous system side effects of ARIPiprazole such as dizziness, drowsiness, and difficulty concentrating. Some people may also experience impairment in thinking and judgment.
You should avoid or limit the use of alcohol while being treated with ARIPiprazole
.
How often is Aristada given?
The recommended ARISTADA dosing interval is
monthly for the 441 mg, 662 mg and 882 mg doses, every 6 weeks for the 882 mg dose, or every 2 months for the 1064 mg dose
and should be maintained. In the event of early dosing, an ARISTADA injection should not be given earlier than 14 days after the previous injection.
How many ml is Abilify Maintena 400 mg?
Abilify Maintena comes in two forms: Single dose prefilled dual chamber syringe kits for 300 mg (injection volume of 1.5 ml) and 400 mg doses (injection volume of
2.0 ml
) – fewer steps and components. This formulation should be utilized within 30 minutes of reconstitution.
What is the difference between Abilify Maintena and Aristada?
Official Answer. Abilify Maintena (aripiprazole) and Aristada (aripiprazole lauroxil) contain an atypical antipsychotic. They are both used to treat adults with schizophrenia.
Aristada contains aripiprazole lauroxil – a prodrug of aripiprazole – which is the active ingredient in Abilify Maintena
.
Can Abilify be given as a shot?
The recommended initial dose for ABILIFY solution for injection is 9.75 mg (1.3 mL), administered as a single intramuscular injection
. The effective dose range of ABILIFY solution for injection is 5.25 mg to 15 mg as a single injection.
How does ABILIFY MAINTENA work in the brain?
Aripiprazole works
by acting on various receptors in the brain, particularly dopamine receptors and serotonin (5HT) receptors
. Dopamine and serotonin are natural compounds called neurotransmitters, and are involved in transmitting messages between brain cells.
How long does it take for Abilify injections to work?
You can expect aripiprazole (Abilify) to start working in
1 to 2 weeks
, but it may take several weeks until it takes full effect. Some people may see continued improvement on this medication during the first 3 to 4 months of taking it.
Can you switch from ARISTADA to Abilify Maintena?
(Therapeutic drug monitoring along with clinical assessments will lead you to the best dose for your patient!)
Patients treated with Abilify Maintena 400 mg monthly at steady state can be converted safely to and stabilized on Aristada 882 mg at 4 weeks following the last Abilify Maintena administration
.
What is Abilify Maintena approved for?
FDA Approves Once-Monthly ABILIFY MAINTENATM (Aripiprazole) For
Extended-Release Injectable Suspension for the Treatment of Schizophrenia
. Approval provides patients with schizophrenia the ability to access the efficacy and safety profile of oral aripiprazole in a once-monthly formulation.
How long is Abilify Maintena good after reconstitution?
It should only be administered by a healthcare professional. Abilify Maintena powder and solvent for prolonged-release suspension for injection The suspension should be injected immediately after reconstitution but can be stored below 25 °C for
up to 4 hours
in the vial.
Is there a generic for Abilify Maintena?
Abilify Maintena is the brand name for aripiprazole. It comes as an extended-release injectable suspension that is typically administered by a healthcare professional.
There are currently no generic versions of Abilify Maintenat
.
How do you wean off Abilify Maintena?
The dose can be lowered to 300 mg monthly after the first dose as needed for tolerability
. aripiprazole for 14 days with the next administered injection. aripiprazole for 14 days with the next administered injection.
