Indeed,
only two drugs commonly used by anesthesiologists still contain sulfite
: curare and the generic form of propofol, which was recently approved by the FDA despite its decade-old admonition to avoid this agent. The incidence of sulfite allergy is estimated at > 1 in 1,000 patients.
Does propofol contain sulfa?
Recently, serious side effects have been reported, including an acute anaphylactic reaction to generic propofol that contains sodium bisulfite. This
sulfa allergy can cause death
if propofol with the bisulfite is used.
What medications contain sulphites?
- adrenaline (epinephrine), isoprenaline, phenylephrine.
- dexamethasone and some other injectable corticosteroids.
- dopamine.
- local and dental anaesthetics containing adrenaline.
- aminoglycoside antibiotics.
Are there sulfites in anesthesia?
Recently, the injectable local anesthetics procain and novacain which contain sulfites have been shown to cause allergic reactions. The most commonly used local anesthetics, the amide types,
do not contain sulfites unless
combined with epinepherine, a hormone used to prolong the effects of anesthetics.
What are the ingredients in propofol?
The octanol/water partition coefficient for propofol is 6761:1 at a pH of 6 to 8.5. In addition to the active component, propofol, the formulation also contains
soybean oil (100 mg/mL), glycerol (22.5 mg/mL), egg lecithin (12 mg/mL); and disodium edetate (0.005%); with sodium hydroxide
to adjust pH.
Who shouldnt take propofol?
You should not receive propofol if you are allergic to it
. To make sure propofol is safe for you, tell your doctor if you have: epilepsy or other seizure disorder; or. high cholesterol or triglycerides (a type of fat in the blood).
Is there a reversal agent for propofol?
Reversal agents exist for each class of drugs used in sedative procedures
(unfortunately, propofol does not have a reversal agent)
. The current reversal agents, flumazenil for benzodiazepines and naloxone for opioids, work by binding to the same receptors that the sedative or opiate drug attaches to.
Are eggs high in sulfites?
Sulfites also occur naturally in a number of foods such as maple syrup, pectin, salmon, dried cod, corn starch, lettuce, tomatoes, soy products, eggs, onions, garlic, chives, leeks and asparagus. Generally, sulfite sensitivity is found in people with asthma who are steroid dependent.
What does sulphites do to the body?
Exposure to sulphites has been reported to induce a range of adverse clinical effects in sensitive individuals, ranging from dermatitis, urticaria, flushing, hypotension, abdominal pain and diarrhoea to
life-threatening anaphylactic and asthmatic reactions
.
Why are sulphites bad for you?
Sulphites
can trigger asthma and symptoms of an anaphylactic reaction
. Many people who have asthma may also have a sulphite sensitivity. An allergist can confirm sulphite sensitivity. In this case, sulphites need to be avoided.
Does all propofol contain EDTA?
Propofol Injectable Emulsion is a single access parenteral product (single patient infusion vial) which contains
0.005% edetate disodium
(EDTA) to inhibit the rate of growth of microorganisms, for up to 12 hours, in the event of accidental extrinsic contamination.
Who makes Propofol?
Fresenius Kabi
is the U.S. market leader, and we’re committed to meeting Diprivan demand with continuous supply. Diprivan
®
. The Propofol you trust. Diprivan has been there for your physicians and your patients.
Does epinephrine contain sulfite?
While
epinephrine does contain sulfites
, it is the only treatment for anaphylaxis and should not be avoided by individuals allergic to sulfites. Epinephrine hasn’t been reported to cause any allergic reactions.
What does propofol do to the body?
Propofol (Diprivan) slows the activity of your brain and nervous system. Propofol is used
to put you to sleep and keep you asleep during general anesthesia for
surgery or other medical procedures.
What can be used instead of propofol?
Midazolam and fentanyl
are the mainstay of conscious sedation in GI endoscopy.
Can you feel pain with propofol?
What side effects does propofol have? It can cause a decrease in blood pressure, it can depress or even stop breathing, and
it can cause pain on injection
.
