Due to poor oral absorption
, aminoglycosides including streptomycin are administered parenterally. Streptomycin is available as an intramuscular injection, and in some cases may be administered intravenously.
What was the problem with streptomycin?
The following reactions are common: vestibular ototoxicity
(nausea, vomiting, and vertigo); paresthesia of face
; rash; fever; urticaria; angioneurotic edema; and eosinophilia.
How is streptomycin administered?
Streptomycin is an aminoglycoside antibiotic that is indicated for the treatment of tuberculous and nontuberculous infections.
Intramuscular injection
is the recommended route of administration.
Why streptomycin is not given IV?
Streptomycin is administered by deep intramuscular injections and, in both Europe and the USA,
the manufacturers do not recommend intravenous administration
. However, repeated intramuscular injections of streptomycin produce pain and inflammation.
Why streptomycin is no longer used?
Streptomycin was the first effective antituberculosis drug but is no longer a first-line drug as
it has the disadvantage that it is not absorbed from the intestine and must therefore be given by intramuscular injection
. This raises the associated danger of transmission of HIV and other viruses by contaminated needles.
Who should not take streptomycin?
The risk is higher if you have
kidney disease
, if you are receiving high doses of this medication, if you use this drug for a long time, if you are an older adult (older than 60 years), or if you develop a severe loss of body water (become dehydrated).
What is the most serious toxic effect of streptomycin?
Streptomycin injection is usually used for serious bacterial infections for which other medicines may not work. However, it may also cause some serious side effects, including
damage to your hearing and sense of balance
. These side effects may be more likely to occur in elderly patients and newborn infants.
Where do you inject streptomycin?
Give by IM inj into
gluteus maximus or mid-lateral thigh
. Alternate injection sites. 15mg/kg (max 1g) once daily, or 25–30mg/kg (max 1.5g) two or three times weekly. Max 120g over entire course of therapy.
When do you give streptomycin in TB?
Streptomycin is also indicated for therapy of tuberculosis
when one or more of the above drugs is contraindicated because of toxicity or intolerance
. The management of tuberculosis has become more complex as a consequence of increasing rates of drug resistance and concomitant HIV infection.
Why is streptomycin so effective?
Streptomycin is an
effective antibiotic because its structure is similar to that of the anticodons that would usually bind to the ribosome
. Streptomycin is significant because it was the first antibiotic that could treat tuberculosis. Over time, bacteria have become resistant to streptomycin.
What is streptomycin injection for?
STREPTOMYCIN (strep toe MYE sin) is an aminoglycoside antibiotic. It is used to
treat certain kinds of bacterial infections
. It will not work for colds, flu, or other viral infections.
Which injection is used for tuberculosis?
The most commonly used diagnostic tool for tuberculosis is a skin test, though blood tests are becoming more commonplace. A small amount of a substance called
tuberculin
is injected just below the skin on the inside of your forearm. You should feel only a slight needle prick.
Is streptomycin an antifungal?
| ChEBI Name streptomycin | ChEBI ID CHEBI:17076 |
|---|
Is streptomycin still used today?
Streptomycin was discovered in 1943. It was the first antibiotic discovered that was effective against TB.
Today it is widely used as a first line TB medicine in patients that have previously been treated for TB
.
What bacteria is resistant to streptomycin?
More recently, mutations in rRNA genes have been found to be associated with in vivo acquired drug resistance in bacterial pathogens, e.g., in
Mycobacterium tuberculosis
resistant to streptomycin (10); most of the mutations found mapped to the 530 region of 16S rRNA (15, 27).
What is the fastest way to cure TB?
- 2 antibiotics (isoniazid and rifampicin) for 6 months.
- 2 additional antibiotics (pyrazinamide and ethambutol) for the first 2 months of the 6-month treatment period.
