Can 5-HTP Make Anxiety Worse?

by | Last updated on January 24, 2024

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Early research shows that taking 25-150 mg of 5-HTP by mouth daily along with carbidopa seems to reduce anxiety symptoms in people with anxiety disorders. However, other early research shows that

taking higher doses of 5-HTP, 225 mg daily or more, seems to make anxiety worse

.

Can 5-HTP make you feel depressed?

The effects of 5-HTP on symptoms of depression have been well studied. While the exact cause of depression

is largely unknown

, some researchers believe that a serotonin imbalance may influence your mood in a way that leads to depression ( 14 , 15 ).

Can 5 HTP make you feel worse?

Some people may experience nausea, diarrhea, vomiting and stomach pain when taking 5-HTP supplements. These side effects are dose-dependent, meaning they get

worse when increasing your dose

( 33 ).

Is there a downside to taking 5-HTP?

Side effects of 5-HTP are generally mild and may include

nausea, heartburn, gas, feelings of fullness

, and rumbling sensations in some people. At high doses, serotonin syndrome, a dangerous condition caused by too much serotonin in the body, could develop.

Can 5-HTP make you irritable?

Even if you happen to get a pure batch of 5-HTP, the supplement’s effects may not always be benign.

Users can become manic, restless, irritable

, and (though it’s less common) depressed, according to a study in the Archives of Neurology. That’s all the more reason to use 5-HTP with caution — or to steer clear of it.

Should you take 5-HTP at night or morning?

Its levels begin to rise in the evening to promote sleep and fall

in the morning

to help wake you up. Therefore, supplementing with 5-HTP may promote sleep by increasing melatonin production in your body.

Is it OK to take 5-HTP everyday?

When taken by mouth:

It is possibly safe to take 5-HTP in doses of up to 400 mg daily for up to one year

. The most common side effects include heartburn, stomach pain, nausea, vomiting, diarrhea, drowsiness, sexual problems, and muscle problems. Large doses of 5-HTP, such as 6-10 grams daily, are possibly unsafe.

Why is 5-HTP banned in Ireland?

The ban came into place

after a contaminated batch of tryptophan caused the deaths of at least 30 individuals and made more than 1,500 people very sick

. As 5-HTP is a precursor to serotonin, it is a suitable alternative to tryptophan supplements.

Is 5-HTP bad for your liver?


There is a small risk of developing liver toxicity

when using 5-HTP. L-tryptophan, a closely related chemical, was pulled from shelves in 1989 when it was associated with liver failure in a few people taking the supplement.

Does 5-HTP make you happy?

The more of this natural chemical present, the happier you are, hence

its reputation as the happy hormone

. Serotonin levels can be boosted by eating meat, poultry and cheese, taking exercise, or by supplementing with 5-HTP.

Why is 5-HTP banned?

The ban came into place

after a contaminated batch of tryptophan caused the deaths of at least 30 individuals and made more than 1,500 people very sick

. As 5-HTP is a precursor to serotonin, it is a suitable alternative to tryptophan supplements.

Is 5-HTP better than antidepressants?

The 5-HTP was found to be as effective as the antidepressant, with fewer side effects. The small study that did meet the quality criteria found that 5

-HTP worked better than placebo at alleviating depression

.

How long does 5-HTP last in your system?

The biological half-life of 5-HTP ranged from

2.2 to 7.4 hours

, and the plasma clearance

How much 5-HTP should I take for anxiety?

In over 20 years as an integrative psychiatrist, I have found that 5-HTP—

50 milligrams to 100 milligrams taken three times a day

—is a safe and effective approach for chronic generalized anxiety that is well tolerated without excessive daytime sedation.

Can 5-HTP keep you awake at night?

Can 5-HTP cause insomnia? There have been isolated reports of temporary insomnia after taking 5-HTP, but they are rare and most have been found to be related to taking too much of it. This can produce a sudden spike in serotonin levels and

cause shivering and anxiety

, which can keep you awake.

Should 5-HTP be taken on an empty stomach?

They state their 5-HTP capsules may help improve sleep and suggest

taking it before bed on an empty stomach

.

Carlos Perez
Author
Carlos Perez
Carlos Perez is an education expert and teacher with over 20 years of experience working with youth. He holds a degree in education and has taught in both public and private schools, as well as in community-based organizations. Carlos is passionate about empowering young people and helping them reach their full potential through education and mentorship.