What drugs should not be taken with valproic acid? Some products that may interact with this drug include: certain antidepressants (such as amitriptyline, nortriptyline, phenelzine), certain antibiotics (carbapenems such as imipenem), irinotecan, mefloquine, orlistat, other medications for seizure (such as ethosuximide, lamotrigine, phenytoin, rufinamide, topiramate), …
What is the adverse effect of valproic acid?
Diarrhea, dizziness, drowsiness, hair loss, blurred/double vision, change in menstrual periods, ringing in the ears, shakiness (tremor), unsteadiness, weight changes
may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.
What are the long term side effects of valproic acid?
There is no evidence that long-term use of valproic acid will cause
gradual damage to the liver
. Another rare reaction to valproic acid is a disorder of the pancreas. Occasionally it is so severe that bleeding and death can occur.
Can you take Tylenol with valproic acid?
Interactions between your drugs
No interactions were found between Tylenol and valproic acid
. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.
Can you take valproic acid with amoxicillin?
Conclusions.
There were no significant effects on the pharmacokinetics of valproic acid following multiple doses of amoxicillin/clavulanate
, thereby no dose adjustment is necessary.
If you are a woman of childbearing age,
talk to your doctor before using valproic acid together with ALPRAZolam
. Combining these medications may increase the risk of harmful effects to a fetus. It is important to tell your doctor about all other medications you use, including vitamins and herbs.
Interactions between your drugs
No interactions were found between Keppra and valproic acid
.
The biggest difference between Depakene and Depakote lies in how the body breaks them down.
Depakene is made of valproic acid only
. Depakote is made by combining valproic acid and sodium valproate (another similar chemical) in a lab.
Valproic acid can be effective against many types of seizures common in children:
absence seizures
(this is one of the most effective medicines for these brief staring spells) myoclonic seizures. tonic-clonic seizures, such as those in Lennox-Gastaut syndrome.
Do not stop taking valproic acid without talking to your doctor, even
if you experience side effects such as unusual changes in behavior or mood or if you find out that you are pregnant
. If you suddenly stop taking valproic acid, you may experience a severe, long-lasting and possibly life-threatening seizure.
Valproic acid
may cause some people to be agitated, irritable, or display other abnormal behaviors
. It may also cause some people to have suicidal thoughts and tendencies or to become more depressed. If you notice any of these side effects, tell your doctor right away.
More importantly and not uncommonly,
valproate can cause several forms of clinically apparent hepatotoxicity
. Indeed, more than 100 fatal cases of acute or chronic liver injury due to valproate have been reported in the literature.
Pancreatitis (swelling and damage of the pancreas) has also been reported, including in people who’ve taken Depakote for years.
Liver damage and pancreatitis
are long-term side effects. Depakote and Depakote ER have a boxed warning for risk of liver damage and pancreatitis.
Anticonvulsants are sometimes taken to treat the manic episodes associated with bipolar disorder. Depakote is sometimes prescribed when patients experience rapid cycling of mood episodes and works by
calming the hyperactivity of the brain during mania
.
valproic acid diphenhydrAMINE
Using valproic acid together with diphenhydrAMINE may increase side effects such as dizziness, drowsiness, confusion, and difficulty concentrating
. Some people, especially the elderly, may also experience impairment in thinking, judgment, and motor coordination.
valproic acid escitalopram
Treatment with escitalopram may occasionally cause blood sodium levels to get too low
, a condition known as hyponatremia, and using it with some anticonvulsants can increase that risk.
| Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. |
|---|
Valproic acid is used
to treat certain types of seizures (epilepsy)
. This medicine is an anticonvulsant that works in the brain tissue to stop seizures.
The biggest difference between Depakene and Depakote lies in how the body breaks them down.
Depakene is made of valproic acid only
. Depakote is made by combining valproic acid and sodium valproate (another similar chemical) in a lab.
