1. If phytonadione is to administered intravenously,
dilute in 50 ml of normal saline or dextrose solution
and administer over 60 minutes. Monitor vital signs every 15 minutes x 4, then every 30 minutes x 2. IV phytonadione is never given IV push.
Is vitamin K given IV or IM?
Vitamin K is available in injectable and oral formulations. According to the product's labeling, vitamin K solution for injection can
be administered intravenously, intramuscularly
, and subcutaneously with higher preference for the subcutaneous route due to the risk of anaphylaxis with the intravenous route.
What is the route of administration of vitamin K?
Vitamin K is available in injectable and oral formulations. According to the product's labeling, vitamin K solution for injection can be administered
intravenously, intramuscularly, and subcutaneously
with higher preference for the subcutaneous route due to the risk of anaphylaxis with the intravenous route.
When do you administer vitamin K to INR?
Vitamin K given orally is more effective than subcutaneous vitamin K injection, and as effective as intravenous administration when INR values
are compared 24 hours after administration
. A 1.0-mg vitamin K dose is likely most appropriate for patients with INR values between 4.5 and 10.
Can vitamin K be given IV?
Vitamin K is available in injectable and oral formulations. According to the product's labeling, vitamin K solution for
injection can be administered intravenously, intramuscularly
, and subcutaneously with higher preference for the subcutaneous route due to the risk of anaphylaxis with the intravenous route.
Can Vit K be given IM?
Therefore, SC injection of vitamin K is not recommended. Intramuscular
(IM) injection of vitamin K should never be used
. Efficacy data are lacking, and patients with high INR values are at risk of hematoma formation at the injection site.
What is vitamin K IV used for?
Vitamin K is used to treat and prevent low levels of certain substances (
blood clotting factors
) that your body naturally produces. These substances help your blood to thicken and stop bleeding normally (e.g., after an accidental cut or injury).
Why vitamin K injection is given?
Vitamin K
helps the blood to clot and prevents serious bleeding
. In newborns, vitamin K injections can prevent a now rare, but potentially fatal, bleeding disorder called ‘vitamin K deficiency bleeding' (VKDB), also known as ‘haemorrhagic disease of the newborn' (HDN).
What is route of administration Vit K in newborns?
Since 1961, the American Academy of Pediatrics (AAP) has recommended that a single 0.5 mg to 1.0 mg dose of vitamin K be administered
intramuscularly (IM)
to all newborns shortly after birth to prevent VKDB.
How long does IV vitamin K stay in your system?
Supplemental vitamin K can last
up to two weeks
and may impact therapeutic anticoagulation when given.
How much does Vit K decrease INR?
A dose of 1-2.5mg of oral phytomenadione (vitamin K(1)), reduces the range of INR from
5.0-9.0 to 2.0-5.0 within 24-48 hours
, and for an INR >10.0, a dose of 5mg may be more appropriate. Overcorrection of the INR or resistance to warfarin is unlikely if the above doses of vitamin K are used.
How much vitamin K is safe?
How much vitamin K do I need? Adults need
approximately 1 microgram a day of vitamin K for each kilogram of their body weight
. For example, someone who weighs 65kg would need 65 micrograms a day of vitamin K, while a person who weighs 75kg would need 75 micrograms a day.
Does vitamin K decrease INR?
Vitamin K can change how warfarin works, which changes your INR.
Vitamin K lowers your INR values
. The lower your INR, the less time it takes for your blood to clot.
What happens with too much vitamin K?
The effects of vitamin K toxicity can include
jaundice in newborns
, hemolytic anemia, and hyperbilirubinemia. Toxicity also blocks the effects of oral anticoagulants.
Is vitamin K used to stop bleeding?
Vitamin K is used to
prevent and treat certain blood clotting
(coagulation) issues. It's also used to prevent severe bleeding (hemorrhagic disease) in newborns. Vitamin K may be used in cases of ongoing IV feeding. It may also be used when antibiotics have killed bacteria in the intestines that make vitamin K.
Why is vitamin K given in liver disease?
Vitamin K occupies a central role in the
relationship between the liver and the coagulation system since it is required for the synthesis of functionally active forms of a number of coagulation factors and inhibitors by the liver
, including prothrombin, factor VII (FVII), FXI, FX, protein C, and protein S.
