Insulin glargine is metabolized
in the liver into two active metabolites
with similar activity to insulin: 21a-Gly-human insulin (M1) and 21a-Gly-des-30b- threonine insulin (M2), with M1 being the predominant metabolite.
How is Lantus metabolised?
Mechanism of Action: The primary activity of insulin, including insulin glargine, is regulation of
glucose metabolism
. Insulin and its analogs lower blood glucose levels by stimulating peripheral glucose uptake, especially by skeletal muscle and fat, and by inhibiting hepatic glucose production.
How is insulin glargine absorbed?
After injection into the subcutaneous tissue, the acidic solution is neutralized, leading to the formation of microprecipitates from which small amounts of insulin glargine are slowly released; this results in absorption over a
period of approximately 24 hours with
no pronounced peak.
Is Lantus made from human insulin?
LANTUS (insulin glargine injection) is a sterile solution of insulin glargine for subcutaneous use. Insulin glargine is a
recombinant human insulin analog
that is a long-acting, parenteral blood-glucose-lowering agent [see CLINICAL PHARMACOLOGY].
How long does Lantus stay active in your system?
They keep working in the background to keep your blood sugar under control throughout your daily routine. There are currently four different long-acting insulin products available: insulin glargine (Lantus), lasts
up to 24 hours
. insulin detemir (Levemir), lasts 18 to 23 hours.
Why is Lantus given at night?
Lantus is designed to
give a steady level of insulin over 24 hours
, even when you are not eating such as between meals and overnight. This helps keep blood glucose levels consistent during the day and at night.
What are the side effects of taking Lantus insulin?
- A rash over your whole body.
- Trouble breathing.
- A fast heartbeat.
- Sweating.
- Swelling of your face, throat, or tongue.
- Shortness of breath.
- Extreme drowsiness, confusion, or dizziness.
What is the most effective injection site for insulin?
- The belly, at least 5 cm (2 in.) from the belly button. The belly is the best place to inject insulin. …
- The front of the thighs. Insulin usually is absorbed more slowly from this site. …
- The back of the upper arms.
- The upper buttocks.
Where does insulin absorbed fastest?
The abdomen
is generally the subcutaneous injection site with the fastest absorption rate. The arms have an average absorption rate, while the buttocks and thighs have a slower absorption rate.
What does insulin glargine interact with?
Pain medications
Taking pain drugs called salicylates with insulin glargine may increase the
blood sugar
-lowering effect of insulin glargine. This may raise your risk of low blood sugar. If you need to take these drugs with insulin glargine, your doctor may decrease your dosage of insulin glargine.
Is there a cheaper insulin than Lantus?
Basaglar
contains the same kind of insulin as Lantus (insulin glargine), and while it is cheaper—Basaglar costs about 15% less than Lantus—it is still expensive, with a cash price of around $450 for a 30-day supply.
Does Lantus make you gain weight?
Weight gain is one of the most common side effects of Lantus. In clinical studies, the average weight gain was:
up to 1.5 pounds (lb) in adults
with type 1 diabetes who took Lantus over 16 to 28 weeks. up to 4.8 lb in children with type 1 diabetes who took Lantus and regular insulin for 28 weeks.
When should you not take Lantus?
You should not use Lantus if you are having an
episode of hypoglycemia (low blood sugar)
, or if you are in a state of diabetic ketoacidosis (call your doctor for treatment). Never share a Lantus injection pen or cartridge with another person.
Is 50 units of Lantus a lot?
It is possible that the
“maximum” of 50 units is derived
from the technical limitations of the 1/2 mL syringe. The Lantus SoloStar disposable pen has a maximum “dial-able” dose of 80 units. Aside from this technical maximum, there is no mention of a maximum dose in the package insert.
How long does it take for Lantus to lower blood sugar?
Long-acting: It begins working
around four hours after injection
and it has the ability to work for up to 24 hours. These insulins do not peak but are steady throughout the day. Examples of long-acting insulin including glargine (Lantus) and detemir (Levemir).
What happens if you take Lantus twice?
Do NOT use a double dose of your insulin. If you double a dose, this may
cause low blood sugar levels
. High blood sugar levels over a period of time can lead to too much acid in the blood (diabetic ketoacidosis).
