It is metabolised by the liver with a half life of 17 hours . This is prolonged in patients with liver or kidney impairment.
How long do terbinafine side effects last?
Taste disturbance may resolve within several weeks after discontinuation of treatment, but may be prolonged (greater than 1 year), or may be permanent. If symptoms of a taste disturbance occur, Lamisil Tablets should be discontinued.
Can I just stop taking terbinafine?
Since fungal infections may be very slow to clear up, you may need to take terbinafine for several weeks or months. If you stop taking terbinafine too soon, your symptoms may return . Terbinafine works best when there is a constant amount in the blood. To help keep the amount constant, do not miss any doses.
What happens after terbinafine?
Symptoms may include: skin rash, fever, swollen glands , flu-like symptoms, muscle aches, severe weakness, unusual bruising, or yellowing of your skin or eyes. This reaction may occur several weeks after you began using terbinafine.
Is liver damage from terbinafine reversible?
Most cases of acute hepatic injury from terbinafine resolve within 3 to 6 months of stopping the medication. In some instances, however, the injury is severe and unremitting, leading to acute liver failure and either death or need for liver transplantation.
What should you not take with terbinafine?
Avoid caffeine (coffee, soda, chocolate) while you are using this medicine. Terbinafine may cause caffeine to stay in your body longer than usual.
What does terbinafine do to the body?
Terbinafine works by killing the fungus that is causing the infection . It makes holes in the cell membrane of the fungus and the contents leak out. This kills the fungus and treats the infection. If you are taking terbinafine to prevent an infection, the medicine kills any fungus as it starts to appear.
Is weight gain a side effect of terbinafine?
swelling, rapid weight gain , little or no urinating; blood in your urine or stools; weight loss due to taste changes or loss of appetite; or. skin sores, butterfly-shaped skin rash on your cheeks and nose (worsens in sunlight).
How does terbinafine affect the liver?
Some people taking terbinafine have developed severe liver damage leading to liver transplant or death . Call your doctor at once if you have symptoms of liver damage, such as nausea, upper stomach pain, vomiting, loss of appetite, tiredness, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).
Does terbinafine make your hair fall out?
There have been reports of side effects with terbinafine, including hepatitis [295, 296], pancytopenia [295, 297], hair loss [298] , and drug interaction with tricyclic antidepressants [299, 300].
Does Lamisil cause permanent liver damage?
This drug has rarely caused very serious (possibly fatal) liver disease . Get medical help right away if you develop symptoms of liver disease, including: persistent nausea/vomiting, loss of appetite, severe stomach/abdominal pain, dark urine, yellowing eyes/skin. A very serious allergic reaction to this drug is rare.
What is the safest oral antifungal?
Fluconazole has been offered as a single 150- to 300-mg weekly dose for 2-4 weeks and is the safest oral agent. Itraconazole is usually given at 200 mg/d for 7 days.
What are three possible side effects of oral antifungals?
Minor side effects include headache, stomach upset, diarrhea, rash, itch, and loss of taste . Antifungal pills can be expensive. Pills may not work, or the infection may come back. Your nail may still look bad after treatment.
What is the best time of day to take terbinafine?
Timing: Take terbinafine tablets at the same time each day, either in the morning OR in the evening . You can take terbinafine with or without food. Missed dose: If you forget to take your dose, take it as soon as you remember that day.
Can terbinafine affect your menstrual cycle?
You may have problems , such as bleeding between periods, while you are taking Lamisil tablets. You may need to take different amounts of your medicines or you may need to take different medicines. Your doctor and pharmacist have more information.
Why should I avoid caffeine while taking terbinafine?
Terbinafine (Lamisil) can decrease how fast the body gets rid of caffeine. Taking caffeine along with terbinafine (Lamisil) can increase the risk of caffeine side effects including jitteriness, headache, increased heartbeat, and other effects.
