47, XXY (KS) is the most common human sex chromosome disorder
How often does XYY syndrome occur?
XYY syndrome is a rare chromosomal disorder present at birth that affects only males. It is estimated to occur in
approximately one in 1,000 live births
.
How frequently does Klinefelter syndrome occur in humans?
Klinefelter syndrome affects
around 1 in every 660 males
.
How common is XXY in humans?
Scientists believe the XXY condition is one of the most common chromosome abnormalities
What percentage of the population has Klinefelter syndrome?
Klinefelter syndrome is one of the most common chromosomal abnormalities. About 1 in every 500 to 800 males is born with this disorder; approximately 3000 affected boys are born each year in the United Sates.
About 3% of the infertile male population
have Klinefelter syndrome.
What is the survival rate of Klinefelter syndrome?
We found that Klinefelter syndrome was associated with a significant increase in mortality risk of 40% (hazard ratio, 1.40; 95% confidence interval, 1.13–1.74), corresponding to a significantly reduced
median survival of 2.1 yr.
Who is most likely to get Klinefelter syndrome?
Klinefelter syndrome results when
a boy is born
with at least 1 extra X chromosome. This is written as XXY. Klinefelter syndrome occurs in about 1 out of 500 to 1,000 baby boys. Women who get pregnant after age 35 are slightly more likely to have a boy with this syndrome than younger women.
Is Klinefelter syndrome considered a disability?
If you or your dependent(s) are diagnosed with Klinefelter Syndrome and experience any of these symptoms, you may be eligible for
disability
benefits from the U.S. Social Security Administration.
CAN XXY have babies?
It is possible that an XXY male could get a woman pregnant naturally
. Although sperm are found in more than 50% of men with KS
3
, low sperm production could make conception very difficult.
Is Klinefelter syndrome considered intersex?
Therefore, according to the NZKA, not all XXY individuals will develop Klinefelter Syndrome, for the Syndrome is simply a form of male hypogonadism, caused by a lack of testosterone: thus
XXY is not an intersex condition
.
Does Klinefelter syndrome run in families?
Klinefelter syndrome is not directly inherited
– the additional X chromosome occurs as a result of either the mother’s egg or the father’s sperm having the extra X chromosome (an equal chance of this happening in either), so after conception the chromosome pattern is XXY rather than XY.
Can Klinefelter syndrome produce sperm?
Most men with
Klinefelter syndrome produce little or no sperm
, but assisted reproductive procedures may make it possible for some men with Klinefelter syndrome to father children.
What is the risk for inheritance of Klinefelter syndrome?
Klinefelter syndrome is not inherited
; the addition of an extra X chromosome occurs during the formation of reproductive cells (eggs or sperm) in one of an affected person’s parents.
Are all Klinefelter’s infertile?
Between 95% and 99% of XXY men are infertile
because they do not produce enough sperm to fertilize an egg naturally. But, sperm are found in more than 50% of men with KS. Advances in assistive reproductive technology (ART) have made it possible for some men with KS to conceive.
How do you know if you have Klinefelter’s syndrome?
Longer legs, shorter torso and broader hips compared with
other boys. Absent, delayed or incomplete puberty. After puberty, less muscle and less facial and body hair compared with other teens. Small, firm testicles.
What is the most common treatment for Klinefelter’s?
One common treatment is
testosterone replacement therapy
. It can start at puberty and can spur typical body changes, such as facial hair and a deeper voice. It can also help with penis size and stronger muscles and bones, but it won’t affect testicle size or fertility.
