HEXTEND (6% Hetastarch in Lactated Electrolyte Injection) is
an artificial colloidal solution
, pharmacologically classified as a plasma volume expander, and is intended to support oncotic pressure as well as provide electrolytes.
Is hextend hypertonic?
Hextend and 7.5%
hypertonic
saline with Dextran are equivalent to Lactated Ringer’s in a swine model of initial resuscitation of uncontrolled hemorrhagic shock. J Trauma.
Is hespan a colloid?
HESPAN
®
(6% hetastarch in 0.9% sodium chloride injection) is a sterile, nonpyrogenic solution for intravenous administration. Hetastarch is a
synthetic colloid
derived from a waxy starch composed almost entirely of amylopectin.
What type of solution is Hetastarch?
Hetastarch is an
artificial colloid pharmacologically
classified as a plasma volume expander; 0.9% Sodium Chloride Injection is a fluid and electrolyte replenisher.
Is Hetastarch isotonic?
A synthetic, nonionic hydroxyethyl derivative of starch used as a plasma expander when prepared in an
isotonic solution
. Upon intravenous administration, hydroxyethyl starch colloid increases blood volume and thus improves circulation.
Why is hextend preferred over lactated ringers?
Hextend (BioTime, Inc., Alameda, CA) is a solution of 6% hetastarch in a lactated crystalloid carrier, offering
greater oncotic pressure and potentially better retention of intravascular fluid than standard electrolyte-only crystalloid
.
What is hextend?
HEXTEND (6% Hetastarch in Lactated Electrolyte Injection) is
an artificial colloidal solution
, pharmacologically classified as a plasma volume expander, and is intended to support oncotic pressure as well as provide electrolytes.
When do we use colloid?
There are two types of IVFs, crystalloid and colloid solutions. Crystalloid solutions are used to treat most patients with shock from dengue, while colloids are
reserved for patients with profound or refractory shock
.
What is considered a colloid solution?
A colloid is a
mixture that has particles ranging between 1 and 1000 nanometers in diameter
, yet are still able to remain evenly distributed throughout the solution. … If the dimensions are smaller than this the substance is considered a solution and if they are larger than the substance is a suspension.
Is blood a colloid?
Blood is
a colloid
because in blood the blood cell size is between 1nm to 100nm. A mixture in which one substance is divided into minute particles (called colloidal particles) and dispersed throughout a second substance. … Blood is a colloidal solution of an albuminoid substance.
Is dextran a colloid?
Dextrans are highly branched polysaccharide molecules which are available for use as
an artificial colloid
. They are produced by synthesis using the bacterial enzyme dextran sucrase from the bacterium Leuconostoc mesenteroides (B512 strain) which is growing in a sucrose medium.
Is normal saline a colloid solution?
Fluids used for this purpose are crystalloids or colloids. Crystalloids, such as saline and Ringer’s lactate, are solutions of salt, water and minerals, and are commonly used in the clinical setting. … Colloids, which are suspended in crystalloid solutions, are similarly given for the purpose of volume expansion.
When do you give Hetastarch?
Hetastarch is used to treat or prevent hypovolemia (decreased blood plasma volume, also called “shock”) that may occur as a result
of serious injury, surgery, severe blood loss, burns, or other trauma
. Hetastarch may also be used for purposes not listed in this medication guide.
Why normal saline is not normal?
Saline
is not physiological
Despite its name, saline is neither “normal” nor “physiological”. Compared to human serum, saline has a nearly 10% higher Na concentration and 50% higher Cl concentration.
How much hetastarch is normally used for a patient?
Typically, hetastarch products are given at
doses up to 20 mL/kg/day
. In critical patients, however, the benefits of the product may outweigh the risks of higher doses. For instance, a dose up to 40 to 50 mL/kg/day of hetastarch may be needed to obtain the desired effects.
What is in LR?
Lactated Ringer’s is composed of
sodium chloride 6 g/L, sodium lactate 3.1 g/
L, potassium chloride 0.3 g/L, and calcium chloride 0.2 g/L. Lactated Ringer’s contains ions of sodium 130 mEq/L, potassium 4 mEq/L, calcium 2.7 mEq/L, chloride 109 mEq/L, and lactate 28 mEq/L.
