Propofol infusion syndrome
Is anesthesia hard on kidneys?
All general anesthetics employed clinically have
significant and reversible effects
on renal hemodynamics, water, and electrolyte excretion at concentrations in which they are usually employed for surgical anesthesia. Some of the mechanisms by which these effects are produced are discussed.
What are the long-term side effects of propofol?
Conclusion: The limited data available suggest that long-term infusion of propofol is a practical alternative to use of standard agents for sedation of intubated patients. Adverse effects such as
cardiovascular depression, respiratory depression, and hypertriglyceridemia
may limit the routine use of propofol.
Who should not use propofol?
You should not receive propofol
if you are allergic to it
. To make sure propofol is safe for you, tell your doctor if you have: epilepsy or other seizure disorder; or. high cholesterol or triglycerides (a type of fat in the blood).
Is propofol excreted by the kidneys?
Elimination. Propofol is
mainly eliminated
(73% of the dose in 24 h and 88% in 120 h) by glomerular filtration (renal clearance of 120 ml/min) as water-soluble metabolites and/or bile [108, 109].
How long is propofol in your system?
The half-life of elimination of propofol has been estimated to be
between 2 and 24 hours
. However, its duration of clinical effect is much shorter, because propofol is rapidly distributed into peripheral tissues. When used for IV sedation, a single dose of propofol typically wears off within minutes.
What is the 1 2 life of propofol?
Half-life: Propofol is bi-phasic, with its initial half-life being relatively quick, around 40 minutes, and its terminal half-life usually being
4 to 7 hours
. Context-sensitive half-time may be up to 1 to 3 days after a 10-day infusion. The clinical effect of propofol is much shorter in duration.
Does anesthesia shorten your life?
No other study has investigated the effect of general anesthesia without surgery on life expectancy. This is probably attributable, in part, to the fact that, absent major physiologic abnormalities during or immediately after anesthesia, there
has been no reason
to think that anesthesia affects longevity.
Are you dead under anesthesia?
The risk of dying in the operating theatre under anaesthetic is
extremely small
. For a healthy person having planned surgery, around 1 person may die for every 100,000 general anaesthetics given. Brain damage as a result of having an anaesthetic is so rare that the risk has not been put into numbers.
What is the chance of not waking up from anesthesia?
Two common fears that patients cite about anesthesia are: 1) not waking up or 2) not being put “fully to sleep” and being awake but paralyzed during their procedure. First and foremost, both cases are extremely, extremely rare. In fact, the likelihood of someone dying under anesthesia is
less than 1 in 100,000
.
Can you feel pain on propofol?
What side effects does propofol have? It can cause a decrease in blood pressure, it can depress or even stop breathing, and
it can cause pain on injection
.
What does propofol do to the body?
Like many sedating anesthetics, propofol
lowers blood pressure and suppresses breathing
, so the heart function and breathing of patients need to be constantly monitored.
Can propofol cause memory loss?
Conclusions: Lack of retention of material acquired into long-term memory during propofol administration, associated with minimal sedation, seems to define
drug-induced amnesia
. Sedation seems to impair the acquisition or encoding of material into long-term memory.
What can I use instead of propofol?
Midazolam and fentanyl
are the mainstay of conscious sedation in GI endoscopy. However, they have their drawbacks and certainly cannot fill the place of propofol. They can at best supplement the anesthesia/deep sedation provided by the other drugs discussed here.
What is the main side effect of propofol?
Tell your doctor right away if you have
chest pain
or discomfort, confusion, dark-colored urine, dizziness, drowsiness, lightheadedness, fainting, fever, muscle cramps, spasms, pain, or stiffness, nausea, right upper abdominal or stomach pain and fullness, slow or irregular heartbeat, trouble breathing, stomach cramps, …
How long does it take for propofol to wear off after colonoscopy?
Even under deep sedation, you will not remain asleep for long: That effect usually wears off
within 30 minutes of the removal of the
IV. You may feel bloated or pass gas for a few hours after the exam, but walking could help relieve the discomfort.
