Results from this pilot and open naturalistic study suggest that zonisamide may effectively augment response to anxiolytic medications in patients with
treatment refractory
Is zonisamide a mood stabilizer?
Several preliminary studies of zonisamide have been conducted in bipolar disorder with promising results for efficacy in both the manic
4 – 6
and depressed phases of the illness. In addition to the
putative mood stabilizing
properties of zonisamide, beneficial effects on weight and metabolic parameters have been reported.
What can zonisamide be used for?
Zonisamide is used in combination with other medications to
treat certain types of seizures
. Zonisamide is in a class of medications called anticonvulsants. It works by decreasing abnormal electrical activity in the brain.
Do anti seizure meds help with anxiety?
In fact, anticonvulsant drugs exert their antiseizure activity by decreasing the excessive outbursts from epileptic neurons. Therefore, these drugs could
reduce symptoms of anxiety by decreasing neuronal activation within fear circuits
.
How does zonisamide make you feel?
This medicine may cause some people to be
agitated, irritable, or display other abnormal behaviors
. It may also cause some people to have suicidal thoughts and tendencies or to become more depressed.
Does zonisamide help you sleep?
Carbonic anhydrase inhibition reduces apnoeic events in sleep disordered breathing.
Zonisamide inhibits carbonic anhydrase
, and induces weight loss in obese patients. This study explored the relative influence of these two properties, which may both alleviate obstructive sleep apnoea (OSA).
Does zonisamide make you sleepy?
SIDE EFFECTS: Dizziness,
drowsiness
, trouble sleeping, lack of coordination, lightheadedness, loss of appetite, diarrhea, and double vision may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.
Does zonisamide help with depression?
found that open label zonisamide (mean dose = 222.5 mg) given for 8 weeks to 20 patients with bipolar depression was
associated with significant improvement in MADRS scores
, although 10 patients terminated from the study due to side effects.
What is the safest mood stabilizer?
The safest and most efficacious mood stabilizer combinations appear to be the mixtures of anticonvulsants and lithium, particularly
valproate plus lithium
.
What medication is best for anger?
Prescription and Over-the-Counter Medications
Antidepressants such
as Prozac, Celexa and Zoloft
are commonly prescribed for anger issues. These drugs do not specifically target anger within the body, but they do have a calming effect that can support control of rage and negative emotion.
Do you lose weight on zonisamide?
The zonisamide group (n = 19) had a
mean weight loss of 9.2 kg
(1.7 kg) (9.4% loss) at week 32 compared with 1.5 kg (0.7 kg) (1.8% loss) for the placebo group (n = 17) (t = 4.0; P<. 001). Zonisamide was tolerated well, with few adverse effects.
What drugs should not be taken with zonisamide?
Do not start, stop, or change the dosage of any medicines without your doctor’s approval. Some products that may interact with this drug include: carbonic anhydrase inhibitors (such as
acetazolamide
), orlistat. Other medications can affect the removal of zonisamide from your body, which may affect how zonisamide works.
Is zonisamide a painkiller?
Zonisamide is one of
a type of medicine normally used to treat epilepsy
. Some of these medicines are also useful for treating neuropathic pain. We looked for clinical trials that used zonisamide to treat neuropathic pain. We found a single study with 25 participants treated either with zonisamide or placebo.
Can Keppra worsen anxiety?
As with other antiepileptics, Keppra may increase the risk of suicidal thoughts or behavior. Monitor for worsening depression or mood changes. Keppra may also
cause
behavioral problems such as aggression, anxiety, irritability, and nervousness; advise people taking Keppra to monitor their mood.
Does Keppra reduce anxiety?
Levetiracetam has
been shown to prevent anxiety during sedative withdrawal
, which is similar to alcohol withdrawal, in a laboratory study using mice. Levetiracetam also had anti-anxiety effects in laboratory study using mice.
Is anxiety linked to epilepsy?
Anxiety as a reaction to the diagnosis of epilepsy
People often develop
anxiety after epilepsy is diagnosed
, or after they have their first seizure. In fact, one common cause of anxiety in epilepsy is the fear of having a seizure.
