When Should Fluoxetine Be Increased?

When Should Fluoxetine Be Increased? Consider a dose increase after several weeks if insufficient clinical improvement is observed. Administer doses above 20 mg/day once daily in the morning or twice daily (i.e., morning and noon). The maximum fluoxetine dose should not exceed 80 mg/day. When should I increase my antidepressant? “You should see some improvement