Does Hydrocodone Acetaminophen Cause Headaches?

Does Hydrocodone Acetaminophen Cause Headaches? Does hydrocodone acetaminophen cause headaches? If hydrocodone is used to treat migraines, it can make the accompanying symptoms worse, and it can also cause rebound headaches that can be worse than the original headache. Opioids are not the recommended course of treatment for chronic migraines. Can hydrocodone make headaches worse?