active metabolites

How Is Diazepam Excreted?

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How Is Diazepam Excreted? Diazepam and its metabolites are excreted mainly in the urine, predominantly as their glucuronide conjugates. The clearance of diazepam is 20 to 30 mL/min in young adults. Diazepam accumulates upon multiple dosing and there is some evidence that the terminal elimination half-life is slightly prolonged. Is diazepam metabolized by the liver?

How Do You Break Down Metabolites?

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How Do You Break Down Metabolites? Once in the liver, enzymes convert prodrugs to active metabolites or convert active drugs to inactive forms. The liver’s primary mechanism for metabolizing drugs is via a specific group of cytochrome P-450 enzymes. How drugs are metabolized? Drugs can be metabolized by oxidation, reduction, hydrolysis, hydration, conjugation, condensation, or