active norepinephrine

How Do Tricyclic Antidepressants Affect Norepinephrine? Tricyclic antidepressants act on approximately five different neurotransmitter pathways to achieve their effects. They block the reuptake of serotonin and norepinephrine in presynaptic terminals, which leads to increased concentration of these neurotransmitters in the synaptic cleft. Do antidepressants affect norepinephrine? Norepinephrine and dopamine reuptake inhibitors (NDRIs) are antidepressant medications