acute hypocalcemia

Does High Phosphate Cause Low Calcium? The phosphate builds up in your body and binds to calcium. This causes your calcium levels to decrease, which may weaken your bones. Why does hyperphosphatemia lead to hypocalcemia? By precipitating calcium, decreasing vitamin D production, and interfering with PTH-mediated bone resorption, hyperphosphatemia can cause hypocalcemia; in severe cases,