Can Dogs Take Otc Allergy Pills?

Can Dogs Take Otc Allergy Pills? Antihistamines. Many dogs respond well to human over-the-counter allergy medicine that you can purchase at most drug stores. The most common antihistamine for dogs is diphenhydramine, brand name Benadryl. What allergy pill can I give my dog? Benadryl is a great medication for use in dogs with mild-to-moderate allergies.