What Medicine Cancels Out The Depo Shot?
What Medicine Cancels Out The Depo Shot? Neither antibiotics nor antiseizure medicines reduce Depo-Provera’s effectiveness. The only drug which reduces its effectiveness is aminoglutethimide (Cytadren), used to suppress adrenal function in some people with Cushing syndrome. Research indicates that Depo-Provera even reduces the frequency of seizures. What can make Depo less effective? The antibiotics Rifampin,