What Is The Difference Between 1st And 2nd Generation Antipsychotics?

What Is The Difference Between 1st And 2nd Generation Antipsychotics? First generation antipsychotics are D2 antagonists and are associated with higher risk of EPS. Second generation antipsychotics: are 5HT2A/D2 antagonists, are associated with lower risk of EPS and with higher risk of metabolic side effects. What is the main difference between the two types of