What Role Does Antithrombin III Play In Coagulation?

What Role Does Antithrombin III Play In Coagulation? Antithrombin III (ATIII) is a nonvitamin K-dependent protease that inhibits coagulation by neutralizing the enzymatic activity of thrombin (factors IIa, IXa, Xa). What is antithrombin function? Antithrombin testing measures the activity (function) and the amount (quantity) of antithrombin in an individual’s blood and is used to evaluate