cholesteatoma surgery

How Does Cholesteatoma Cause Bone Erosion? The cholesteatoma causes an inflammatory reaction that releases lytic enzymes, growth factors, and cytokines which can recruit osteoclasts to initiate destruction of bone. Why does cholesteatoma cause bone erosion? Consequently, a growing cholesteatoma can erode and destroy important structures within the temporal bone. Cholesteatomas cause bony erosion by either