Which Chromosomal Abnormality Is Associated With CML?

Which Chromosomal Abnormality Is Associated With CML? An abnormal chromosome called the Philadelphia chromosome Which chromosomal abnormality occurs in CML? Chronic myeloid leukemia (CML) is a clonal myeloproliferative disorder characterized by the presence of the Philadelphia (Ph) chromosome, produced by the reciprocal translocation t(9;22)(q34;q11). Is CML caused by chromosomal rearrangement? It was first identified as