Where Is Big Cypress National Preserve?
Where Is Big Cypress National Preserve? Big Cypress National Preserve Nearest cityEverglades City, Florida Coordinates 25°51′32′′N 81°02′02′′WCoordinates: 25°51′32′′N 81°02′02′′W How do I get to Big Cypress? Take I-75 (Alligator Alley) South to Exit 80, SR-29. Head south on SR-29 (towards Everglades City) 17 miles to where it intersects with US-41 (Tamiami Trail). Turn left onto