cytotoxic drugs

How Do Anthracyclines Work?

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How Do Anthracyclines Work? Anthracyclines are a class of potent and widely used cytotoxic drugs, derived from antibiotics that inhibit DNA and RNA synthesis by intercalating between base pairs of the DNA/RNA strand. They create iron-mediated free oxygen radicals, damaging the DNA and cell membranes, and inhibit topoisomerase II. Are plant alkaloids alkylating agents? Plant

Is Methotrexate A Cytotoxic?

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Is Methotrexate A Cytotoxic? Methotrexate is a folic acid antagonist and is classified as an antimetabolite cytotoxic agent. Why should you not touch methotrexate? Even touching or inhaling the dust from the tablet can allow the medicine to get into the body. Methotrexate goes into sperm, so it’s important that a man taking it doesn’t