What Is The Largest Wetland In The United States?

What Is The Largest Wetland In The United States? Cheyenne Bottoms is a wetland in the central Great Plains of North America. Occupying approximately 41,000 acres (170 km2; 64 sq mi) in central Kansas, it is the largest wetland in the interior United States. What is the largest freshwater wetland in the US? The Okefenokee