What Drugs Have The Longest Half Life?

What Drugs Have The Longest Half Life? What drugs have the longest half life? However, there are numerous other drugs with very long half-life, examples are mefloquine 14–41 days (25), amiodarone 21–78 days (26), and oritavancin 393 h (27). Which drug has the longest elimination half-life? Given fluticasone propionate’s large Vd, it is not surprising