Can I Eat Grapefruit When Taking Ibuprofen?

Can I Eat Grapefruit When Taking Ibuprofen? Can I eat grapefruit when taking ibuprofen? Grapefruit interferes with proteins in the small intestine and liver that normally break down many medications. Eating grapefruit or drinking grapefruit juice while taking these medications can lead to higher levels of them in your blood — and more side effects.