How Long Do EpiPens Last After Expiration?

How Long Do EpiPens Last After Expiration? Injectable epinephrine kits come in various brands, including EpiPen, Twinject, and Avi-Q. All of these devices have a relatively short shelf life due to the instability of epinephrine: approximately one year from the date of manufacture. What happens if you use expired epinephrine? “The greatest risk of using